Chilblains

Definition:

Chilblains, or pernio, is a localized inflammatory lesion of the skin resulting from an abnormal response to cold. It is characterized by persistent purple or purple-red nodules on acral skin, most commonly the feet. Chilblains occurs most commonly among young women between the ages of 15 and 30 years but may occur among older individuals or children. Treatment of chilblains is focused on keeping the affected area warm, and occasionally using vasodilator agents.

References:

[1]. Nameer K Al-Sudany, et al. Treatment of primary perniosis with oral pentoxifylline (a double-blind placebo-controlled randomized therapeutic trial). Dermatol Ther. 2016 Jul;29(4):263-8. [Content Brief]

[2]. Tamara D Simon, et al. Pernio in pediatrics. Pediatrics. 2005 Sep;116(3):e472-5. [Content Brief]

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