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Ensconsin

Definition:

Microtubule-stabilizing protein that may play an important role during reorganization of microtubules during polarization and differentiation of epithelial cells. Associates with microtubules in a dynamic manner. May play a role in the formation of intercellular contacts. Colocalization with TRPV4 results in the redistribution of TRPV4 toward the membrane and may link cytoskeletal microfilaments.

References:

[1]. N Fabre-Jonca, et al. Upregulation and redistribution of E-MAP-115 (epithelial microtubule-associated protein of 115 kDa) in terminally differentiating keratinocytes is coincident with the formation of intercellular contacts. J Invest Dermatol. 1999 Feb;112(2):216-25. [Content Brief]

[2]. J C Bulinski, et al. Rapid dynamics of the microtubule binding of ensconsin in vivo. J Cell Sci. 2001 Nov;114(Pt 21):3885-97. [Content Brief]

[3]. D Masson, et al. Identification and molecular characterization of E-MAP-115, a novel microtubule-associated protein predominantly expressed in epithelial cells. J Cell Biol. 1993 Oct;123(2):357-71. [Content Brief]

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