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Erlin-1

Definition:

Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway. Binds cholesterol and may promote ER retention of the SCAP-SREBF complex.; (Microbial infection) Required early in hepatitis C virus (HCV) infection to initiate RNA replication, and later in the infection to support infectious virus production.

References:

[1]. Christina Whitten-Bauer, et al. The Host Factor Erlin-1 is Required for Efficient Hepatitis C Virus Infection. Cells. 2019 Dec 2;8(12):1555. [Content Brief]

[2]. Michael D Huber, et al. Erlins restrict SREBP activation in the ER and regulate cellular cholesterol homeostasis. J Cell Biol. 2013 Nov 11;203(3):427-36. [Content Brief]

[3]. Margaret M P Pearce, et al. An endoplasmic reticulum (ER) membrane complex composed of SPFH1 and SPFH2 mediates the ER-associated degradation of inositol 1,4,5-trisphosphate receptors. J Biol Chem. 2009 Apr 17;284(16):10433-45. [Content Brief]

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