Exocyst complex component 1

Definition:

Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.; (Microbial infection) Has an antiviral effect against flaviviruses by affecting viral RNA transcription and translation through the sequestration of elongation factor 1-alpha (EEF1A1). This results in decreased viral RNA synthesis and decreased viral protein translation.

References:

[1]. Raghavan Bhuvanakantham, et al. Human Sec3 protein is a novel transcriptional and translational repressor of flavivirus. Cell Microbiol. 2010 Apr 1;12(4):453-72. [Content Brief]

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