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FL5.12

Definition:

FL5.12 is a mouse Pro-B cell factor-dependent cell line derived from Embryonic liver. Its stable in vitro growth supports reproducible mechanistic and pharmacological experiments. FL5.12 is used to investigate cellular phenotype, signal transduction, and pharmacological response in a controlled cellular system.

Verweise:

[1]. Oltvai ZN, Milliman CL, Korsmeyer SJ. Bcl-2 heterodimerizes in vivo with a conserved homolog, Bax, that accelerates programmed cell death. Cell. 1993;74(4):609-19. [Content Brief]

[2]. Simonian PL, et al. Bax can antagonize Bcl-XL during etoposide and cisplatin-induced cell death independently of its heterodimerization with Bcl-XL. The Journal of biological chemistry. 1996;271(37):22764-72.

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