Histoplasmosis

Definition:

Histoplasmosis is a disease caused by the fungus Histoplasma capsulatum that occurs in temperate and tropical climates. It is one of the most frequent invasive fungal infections in immunocompromised patients or patients receiving tumor necrosis factor (TNF) blockers. Most affected patients present with pneumonitis, and sometimes the disease may be disseminated from the lungs to other organs.

References:

[1]. Alison Jazwinski, et al. Immune reconstitution syndrome in a patient with disseminated histoplasmosis and steroid taper: maintaining the perfect balance. Mycoses. 2011 May;54(3):270-2. [Content Brief]

[2]. Ann LeMonte, et al. Evaluation of the IMMY ALPHA Histoplasma antigen enzyme immunoassay for diagnosis of histoplasmosis marked by antigenuria. Clin Vaccine Immunol. 2007 Jun;14(6):802-3. [Content Brief]

[3]. Ashish O Gupta, et al. Immune reconstitution syndrome and fungal infections. Curr Opin Infect Dis. 2011 Dec;24(6):527-33. [Content Brief]

[4]. Chadi A Hage, et al. Recognition, diagnosis, and treatment of histoplasmosis complicating tumor necrosis factor blocker therapy. Clin Infect Dis. 2010 Jan 1;50(1):85-92. [Content Brief]

[5]. John R Perfect, et al. The impact of the host on fungal infections. Am J Med. 2012 Jan;125(1 Suppl):S39-51. [Content Brief]

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