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Ninein

Definition:

Centrosomal protein required in the positioning and anchorage of the microtubule minus-end in epithelial cells. May also act as a centrosome maturation factor. May play a role in microtubule nucleation, by recruiting the gamma-tubulin ring complex to the centrosome. Overexpression does not perturb nucleation or elongation of microtubules but suppresses release of microtubules. Required for centriole organization and microtubule anchoring at the mother centriole.

References:

[1]. Andrew Kodani, et al. Kif3a interacts with Dynactin subunit p150 Glued to organize centriole subdistal appendages. EMBO J. 2013 Feb 20;32(4):597-607. [Content Brief]

[2]. Young Y Ou, et al. CEP110 and ninein are located in a specific domain of the centrosome associated with centrosome maturation. J Cell Sci. 2002 May 1;115(Pt 9):1825-35. [Content Brief]

[3]. Elizabeth E Stillwell, et al. Human ninein is a centrosomal autoantigen recognized by CREST patient sera and plays a regulatory role in microtubule nucleation. Cell Cycle. 2004 Jul;3(7):923-30. [Content Brief]

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