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Probable tRNA

Definition:

Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage. This step is essential for proper recognition of the tRNA and for the fidelity of protein synthesis (Probable). Also functions as a guanyl-nucleotide exchange factor/GEF for the MFN1 and MFN2 mitofusins thereby regulating mitochondrial fusion. By regulating both mitochondrial dynamics and bioenergetic function, it contributes to cell survival following oxidative stress.

References:

[1]. Fionnuala B Hickey, et al. IHG-1 increases mitochondrial fusion and bioenergetic function. Diabetes. 2014 Dec;63(12):4314-25. [Content Brief]

[2]. Simon Edvardson, et al. A mutation in the THG1L gene in a family with cerebellar ataxia and developmental delay. Neurogenetics. 2016 Oct;17(4):219-225. [Content Brief]

[3]. Samantha J Hyde, et al. tRNA(His) guanylyltransferase (THG1), a unique 3'-5' nucleotidyl transferase, shares unexpected structural homology with canonical 5'-3' DNA polymerases. Proc Natl Acad Sci U S A. 2010 Nov 23;107(47):20305-10. [Content Brief]

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