Sentrin-specific protease 5

Definition:

Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO3 to its mature form and deconjugation of SUMO2 and SUMO3 from targeted proteins. Has weak proteolytic activity against full-length SUMO1 or SUMO1 conjugates. Required for cell division.

References:

[1]. Alessandra Di Bacco, et al. The SUMO-specific protease SENP5 is required for cell division. Mol Cell Biol. 2006 Jun;26(12):4489-98. [Content Brief]

[2]. Limin Gong, et al. Characterization of a family of nucleolar SUMO-specific proteases with preference for SUMO-2 or SUMO-3. J Biol Chem. 2006 Jun 9;281(23):15869-77. [Content Brief]

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