Biotin-14-CTP
Biotin-14-CTP is a modified cytidine triphosphate analog, as well as a non-terminating, non-processable nucleotide analog and labeling reagent. Biotin-14-CTP incorporates into nascent RNA strands during transcription elongation, enabling immunolabeling-based visualization of transcription sites. The incorporation of Biotin-14-CTP is inhibited by α-Amanitin (HY-19610), indicating that it can be utilized by RNA polymerase II.
For research use only. We do not sell to patients.
- CAS No.: 208403-22-9
- Formula: C31H54N7O17P3S
- Molecular Weight:921.78
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Biotin-14-CTP (100 µM; 15 min) labels transcription sites in permeabilized HeLa cells that are anchored to a nucleoskeleton, as they remain distributed throughout the nucleus after extensive chromatin removal, with some sites fragmenting into smaller clusters during chromatin elution[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 208403-22-9
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Molecular Weight 921.78
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Formula C31H54N7O17P3S
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SMILES
O[C@@H]1[C@H](O)[C@@H](COP(OP(OP(O)(O)=O)(O)=O)(O)=O)O[C@H]1N2C=CC(NCCCCCCNC(CCCCCNC(CCCC[C@@H]3SC[C@@]4(NC(N[C@@]43[H])=O)[H])=O)=O)=NC2=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Biotin-14-CTP Related Classifications
HY-188058 Related Classifications
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