Acetobixan
Acetobixan is an inhibitor of Cellulose Synthase A6 (CESA6). Acetobixan inhibits cellulose components of Pythium insidiosum cell walls. Acetobixan can be used for the research of Pythium insidiosum keratitis.
For research use only. We do not sell to patients.
- CAS No.: 380201-24-1
- Formula: C16H17NO2S
- Molecular Weight:287.38
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Acetobixan disrupts cellulose biosynthesis in plant cells by dissociating YFP-tagged CESA6 complexes from the plasma membrane[1].
Acetobixan (1-10 μM; 7 days) reduces cellulose content in a concentration-dependent manner in dark-grown wild-type Arabidopsis thaliana seedlings, with significant reductions observed at 5 μM and 10 μM[2].
Acetobixan (50 μM; 1 h) induces relocalization of YFP-CesA6 from the plasma membrane to cytoplasmic vesicles without disrupting cortical microtubules in transgenic Arabidopsis thaliana seedlings[2].
Acetobixan (1-20 μM; 7 days) inhibits root growth in wild-type, ixr1-2, ixr2-1, and aegeus/ags Arabidopsis thaliana seedlings equally, shows concentration-dependent hypocotyl growth inhibition in dark-grown wild-type seedlings[2].
Acetobixan (1 μM) inhibits cellulose biosynthesis in etiolated Arabidopsis thaliana seedlings, reduces plasma membrane-localized cellulose synthase complexes, and inhibits hypocotyl elongation[3].
Acetobixan potently inhibits cellulose biosynthesis in wild-type Arabidopsis thaliana seedlings, inducing severe radial swelling without disrupting cortical microtubule dynamics, and does not exhibit cross-resistance with isoxaben-resistant Arabidopsis thaliana mutants[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 380201-24-1
-
Molecular Weight 287.38
-
Formula C16H17NO2S
-
SMILES
O=C(CSC1=CC=CC=C1)NCC2=CC=CC=C2OC
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
[1]. Gurnani B, et al. Breaking-Down Barriers: Proposal of Using Cellulose Biosynthesis Inhibitors and Cellulase Enzyme as a Novel Treatment Modality for Vision Threatening Pythium Insidiosum Keratitis. Clin Ophthalmol. 2024 Mar 11;18:765-776. [Content Brief]
[2]. Xia Y, et al. Acetobixan, an inhibitor of cellulose synthesis identified by microbial bioprospecting. PLoS One. 2014 Apr 18;9(4):e95245. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)