446-71-9
Chemical Structure
Homoeriodictyol
- CAS No.: 446-71-9
- Formula:C16H14O6
- Molecular Weight:302.28
IUPAC Name: (S)-5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)chroman-4-one
InChIKey: FTODBIPDTXRIGS-ZDUSSCGKSA-N
SMILES: O=C1C[C@@H](C2=CC=C(O)C(OC)=C2)OC3=CC(O)=CC(O)=C13
Biological Activity: Homoeriodictyol is an orally active, bitter-tasting flavanone that can penetrate the blood-brain barrier. Homoeriodictyol enhances synaptic-related protein expression through NCOA4-mediated ferritin autophagy. Homoeriodictyol improves memory impairment in mice by inhibiting the NLRP3 inflammasome. Homoeriodictyol protects human endothelial cells from oxidative damage by activating Nrf2 and inhibiting mitochondrial dysfunction. Homoeriodictyol enhances ROS activity and induces apoptosis, exhibiting anticancer effects. Homoeriodictyol inhibits the survival and migration of androgen-resistant prostate cancer cells in vitro. Homoeriodictyol exerts antinociceptive activity in mice in vivo[1][2][3][4][5][6].
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Homoeriodictyol | 99.86% | Homoeriodictyol is an orally active, bitter-tasting flavanone that can penetrate the blood-brain barrier. Homoeriodictyol enhances synaptic-related protein expression through NCOA4-mediated ferritin autophagy. Homoeriodictyol improves memory impairment in mice by inhibiting the NLRP3 inflammasome. Homoeriodictyol protects human endothelial cells from oxidative damage by activating Nrf2 and inhibiting mitochondrial dysfunction. Homoeriodictyol enhances ROS activity and induces apoptosis, exhibiting anticancer effects. Homoeriodictyol inhibits the survival and migration of androgen-resistant prostate cancer cells in vitro. Homoeriodictyol exerts antinociceptive activity in mice in vivo. | ||||||||||||||||||||
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Homoeriodictyol (Standard) | ≥98% | Homoeriodictyol (Standard) is the analytical standard of Homoeriodictyol (HY-N8210). This product is intended for research and analytical applications. Homoeriodictyol is an orally active, bitter-tasting flavanone that can penetrate the blood-brain barrier. Homoeriodictyol enhances synaptic-related protein expression through NCOA4-mediated ferritin autophagy. Homoeriodictyol improves memory impairment in mice by inhibiting the NLRP3 inflammasome. Homoeriodictyol protects human endothelial cells from oxidative damage by activating Nrf2 and inhibiting mitochondrial dysfunction. Homoeriodictyol enhances ROS activity and induces apoptosis, exhibiting anticancer effects. Homoeriodictyol inhibits the survival and migration of androgen-resistant prostate cancer cells in vitro. Homoeriodictyol exerts antinociceptive activity in mice in vivo. | ||||||||||||||||||||
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- [1]. Zhang M, et al. Hesperidin alleviated dendritic spines through inhibiting ferritinophagy via HERC2-NCOA4 ubiquitination in CUMS mice. Phytomedicine. 2024 Dec;135:156132. [Content Brief]
- [2]. Guo P, et al. Eriodictyol and Homoeriodictyol Improve Memory Impairment in Aβ25-35-Induced Mice by Inhibiting the NLRP3 Inflammasome. Molecules. 2022 Apr 12;27(8):2488. [Content Brief]
- [3]. Shen T, et al. Homoeriodictyol protects human endothelial cells against oxidative insults through activation of Nrf2 and inhibition of mitochondrial dysfunction. Vascul Pharmacol. 2018 Oct;109:72-82. [Content Brief]
- [4]. Quaiser Saquib, et al. Anticancer efficacies of persicogenin and homoeriodictyol isolated from Rhus retinorrhoea. Process Biochemistry, ISSN: 1359-5113, Vol: 95, Page: 186-196.
- [5]. Al-Bzour M H, et al. Exploring the antinociceptive potential of homoeriodictyol in nociception models[J]. J. Pharm. Pharmacogn. Res, 2024, 12: 615-623.
- [6]. Güvenç A, et al. HOMOERIODICTYOL INHIBITS SURVIVAL AND MIGRATION OF ANDROGEN-RESISTANT PROSTATE CANCER CELLS IN VITRO. Exp Oncol. 2025 Jul 11;47(1):34-43. [Content Brief]
