ENPEP - glutamyl aminopeptidase Gene

Also Known as APA; CD249; gp160

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2028

About ENPEP

Cytogenetic location: 4q25 Genomic coordinates (GRCh38): 4:110,476,155-110,565,285 (from NCBI)

This gene has 5 transcripts (splice variants), 207 orthologues and 11 paralogues. Biased expression in small intestine (RPKM 132.9), kidney (RPKM 71.6) and 5 other tissues.

Summary

The ENPEP gene encodes glutamyl Aminopeptidase, a type II integral membrane protein with an extracellular zinc-binding domain. This protein can upregulate blood pressure by cleaving the N-terminal aspartate from angiotensin II, and can regulate blood vessel formation and enhance tumorigenesis in some tissues. Along with ANPEP and DPP4, ENPEP was found to be a candidate co-receptor for the coronavirus SARS-CoV-2, which causes COVID-19. [provided by RefSeq, Apr 2020]

ENPEP Products (4)

mRNA Protein Name
NM_001379611.1 NP_001366540.1 glutamyl aminopeptidase isoform 2
NM_001379612.1 NP_001366541.1 glutamyl aminopeptidase isoform 3
NM_001379613.1 NP_001366542.1 glutamyl aminopeptidase isoform 4
NM_001977.4 NP_001968.3 glutamyl aminopeptidase isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables aminopeptidase activity IDA
IDA: Inferred from direct assay
8244382 GOA
enables metalloaminopeptidase activity IDA
IDA: Inferred from direct assay
8346219 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within cell migration IDA
IDA: Inferred from direct assay
14998491 GOA
acts upstream of or within cell population proliferation IDA
IDA: Inferred from direct assay
14998491 GOA
involved in regulation of systemic arterial blood pressure by renin-angiotensin IDA
IDA: Inferred from direct assay
19608358 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
10692253 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ENPEP Protein Structure

Peptidase_M1

Peptidase_M1: Peptidase family M1 domain (92 - 482)

ERAP1_C

ERAP1_C: ERAP1-like C-terminal domain (616 - 918)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 957 a.a.
Protein Preferred Names Protein Names

glutamyl aminopeptidase

  • AP-A

Recombinant ENPEP Proteins

Cat. No. Product Name Accession Purity
HY-P72824 Aminopeptidase A Protein, Human (sf9, His) Q07075/NP_001968.3 (R41-G957) ≥ 90%, as determined by reducing SDS-PAGE.

ENPEP Antibodies

Cat. No. Product Name Application Reactivity
HY-P82419 AP-A Antibody (YA2164) WB, IHC-P Human

Related Diseases

Diseases Alias
Choriocarcinoma

  • Chorioepithelioma
Retinitis Pigmentosa 71

  • RP71

  • Retinitis Pigmentosa, Type 71
Pre-Eclampsia

  • Preeclampsia

  • Gestational Hypertension

  • Hypertension Induced By Pregnancy

  • Pre-Eclamptic Toxaemia

  • Pregnancy Associated Hypertension

  • Proteinuric Hypertension Of Pregnancy

  • Hypertension, Pregnancy-Induced, Susceptibility To

  • Preeclampsia/Eclampsia

  • Pregnancy Toxemia

  • Toxaemia Of Pregnancy

  • Gestational Proteinuric Hypertension

  • Pregnancy-Induced Hypertension

  • Toxemia Of Pregnancy

  • Preeclampsia, Susceptibility To

  • Transient Hypertension Of Pregnancy

  • Gestational [Pregnancy-Induced] Hypertension Without Significant Proteinuria

  • Gestational Hypertension Nos

  • Mild Proteinuric Hypertension Of Pregnancy

  • Pih - [Pregnancy-Induced Hypertension]

  • Pregnancy-Induced Hypertension Nos

  • Gestational [Pregnancy-Induced] Hypertension With Significant Proteinuria

  • Pe - [Pre-Eclampsia]

  • Pre-Eclampsia Nos

  • Pre-Eclamptic Nos

  • Pregnancy Pre-Eclampsia

  • Puerperal Pre-Eclampsia

  • Pre-Eclampsia Toxaemia

  • Toxaemia In Pregnancy

  • Pet - [Pre-Eclamptic Toxaemia]

  • Maternal Toxaemia
Hypertension, Essential

  • Essential Hypertension

  • Hypertension

  • High Blood Pressure

  • Hypertension, Essential, Susceptibility To

  • Hypertensive Disease

  • Primary Hypertension

  • EHT

  • Hypertension, Salt-Sensitive Essential, Susceptibility To

  • Hyperpiesia

  • Idiopathic Hypertension

  • Hypertensive Disorder

  • Hypertension, Essential, Susceptibility To, 3

  • Hypertension, Essential 3

  • Hypertension, Essential, Salt-Sensitive

  • Hypertension, Essential, Susceptibility To, 6

  • Hypertension, Essential 6

  • Hypertension, Salt-Sensitive Essential

  • Hypertension, Susceptibility To

  • Hypertension, Essential, Susceptibility To, 4

  • Hypertension, Essential 4

  • Hypertension, Essential, Susceptibility To, 2

  • Hypertension, Essential 2

  • Hypertension, Essential, Susceptibility To, 1

  • Hypertension, Essential 1

  • Hypertension, Essential, Susceptibility To, 5

  • Hypertension, Essential 5

  • Htn

  • Vascular Hypertensive Disorder

  • Systemic Primary Arterial Hypertension

  • Hbp - [High Blood Pressure]

  • Systemic Arterial Hypertensive Disorder

  • Elevated Blood Pressure

  • Arterial Hypertension Nos

  • Hypertension Nos

  • Benign Hypertension

  • Systemic Arterial Hypertension

  • Systemic Hypertension

  • Artery Htn

  • Benign Htn

  • Vascular Htn

  • Vascular Hypertension

  • Cholesterol Hypertension

  • Cholesterol Htn

  • Idiopathic Htn

  • Malignant Hypertension

  • Malignant Htn

  • Raised Blood Pressure

  • Cardiovascular Hypertension

  • Primary Htn - [Hypertension]

  • High Arterial Tension

  • High Blood Pressure Disorder

  • Ht - [Hypertension]

  • Htn - [Hypertension]

  • Hypertensive Vascular Disease

  • Hypertensive Vascular Degeneration
Crimean-Congo Hemorrhagic Fever

  • Crimean Hemorrhagic Fever

  • Cchf

  • Congo Hemorrhagic Fever

  • Hemorrhagic Fever, Crimean

  • Chf Congo Virus

  • Congo-Crimean Hemorrhagic Fever

  • Congo Fever

  • Hemorrhagic Fever Crimean-Congo

  • Cchf - [Crimean-Congo Haemorrhagic Fever]

  • Kara Mikh Typhoid Fever

  • Xīnjiāng Haemorrhagic Fever
Long Qt Syndrome

  • Romano-Ward Syndrome

  • Long Q-T Syndrome

  • Lqt

  • Qt Syndrome, Long

  • Congenital Long Qt Syndrome

  • Familial Long Qt Syndrome
Vas Deferens, Congenital Bilateral Aplasia Of

  • Congenital Bilateral Absence Of Vas Deferens

  • CBAVD

  • Cavd

  • Congenital Bilateral Aplasia Of Vas Deferens

  • Congenital Bilateral Absence Of The Vas Deferens

  • Congenital Bilateral Agenesis Of Vas Deferens

  • Absence Of Vas Deferens

  • Absent Vasa

  • Congenital Absence Of Vas Deferens

  • Congenital Aplasia Of Vas Deferens

  • Absent Vas Deferens

  • Vas Deferens, Congenital Bilateral Absence
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04386 ENPEP Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17606 Enpep Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24066 Enpep Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta ENPEP VGNC VGNC:72221
Mus musculus ENPEP MGD MGI:106645
Rattus norvegicus ENPEP RGD RGD:621228
Felis catus ENPEP VGNC VGNC:61871
Canis familiaris ENPEP VGNC VGNC:40373
Bos taurus ENPEP VGNC VGNC:28503
Others ENPEP NCBI