UBXN4 - UBX domain protein 4 Gene

Also Known as UBXD2; UBXDC1; erasin

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 23190

About UBXN4

Cytogenetic location: 2q21.3 Genomic coordinates (GRCh38): 2:135,741,855-135,785,056 (from NCBI)

This gene has 8 transcripts (splice variants), 168 orthologues and 5 paralogues. Ubiquitous expression in thyroid (RPKM 49.4), gall bladder (RPKM 38.6) and 25 other tissues.

Summary

UBXD2 is an integral membrane protein of the endoplasmic reticulum (ER) that binds valosin-containing protein (VCP; MIM 601023) and promotes ER-associated protein degradation (ERAD) (Liang et al., 2006 [PubMed 16968747]).[supplied by OMIM, Mar 2008]

UBXN4 Products (1)

mRNA Protein Name
NM_014607.4 NP_055422.1 UBX domain-containing protein 4

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18775313 GOA
Biological Process GO Annotation Evidence References Source
involved in ERAD pathway IMP
IMP: Inferred from mutant phenotype
19822669 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UBXN4 Protein Structure

UBX

UBX: UBX domain (315 - 393)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 508 a.a.
Protein Preferred Names Protein Names

UBX domain-containing protein 4

  • UBX domain containing 2

UBXN4 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
UBXN4 Q92575 UBQLN1 Homo sapiens Q9UMX0-2
Validated Y2H
25416956
Intra
UBXN4 Q92575 UBQLN1 Homo sapiens Q9UMX0-2
Y2H Array
25416956
Intra
UBXN4 Q92575 UBE4A Homo sapiens Q14139
Pull Down
22119785
Intra
UBXN4 Q92575 UBE4A Homo sapiens Q14139
Anti Tag CoIP
33961781
Intra
UBXN4 Q92575 VCP Homo sapiens P55072
BRET
29997244
Intra
UBXN4 Q92575 VCP Homo sapiens P55072
Lumier
29997244
Intra
UBXN4 Q92575 VCP Homo sapiens P55072
Anti Tag CoIP
18775313
Intra
UBXN4 Q92575 UBQLN1 Homo sapiens Q9UMX0
Y2H Prey Pooling
25416956
Intra
UBXN4 Q92575 UBQLN1 Homo sapiens Q9UMX0
Y2H Prey Pooling
32296183
Intra
UBXN4 Q92575 UBQLN1 Homo sapiens Q9UMX0
Validated Y2H
32296183
Intra
UBXN4 Q92575 UBQLN1 Homo sapiens Q9UMX0
Y2H Array
25416956
Intra
UBXN4 Q92575 UBQLN1 Homo sapiens Q9UMX0
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Inclusion Body Myopathy With Early-Onset Paget Disease Of Bone With Or Without Frontotemporal Dementia 1

  • Ibmpfd1

  • Msp1

  • Multisystem Proteinopathy 1
Martsolf Syndrome 1

  • Martsolf Syndrome

  • Cataract-Intellectual Disability-Hypogonadism Syndrome

  • MARTS1

  • Marts

  • Cataract-Mental Retardation-Hypogonadism

  • Martsolf
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15397 UBXN4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus UBXN4 RGD RGD:1307451
Bos taurus UBXN4 VGNC VGNC:36627
Mus musculus UBXN4 MGD MGI:1915062
Canis familiaris UBXN4 VGNC VGNC:48100
Felis catus UBXN4 VGNC VGNC:80400
Macaca mulatta UBXN4 VGNC VGNC:78968
Others UBXN4 NCBI