CLDN8 - claudin 8 Gene

Also Known as HEL-S-79

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 9073

About CLDN8

Cytogenetic location: 21q22.11 Genomic coordinates (GRCh38): 21:30,214,006-30,216,097 (from NCBI)

This gene has 1 transcript (splice variant), 222 orthologues and 22 paralogues.

Summary

This gene encodes a member of the Claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. This protein plays important roles in the paracellular cation barrier of the distal renal tubule, and in the paracellular barrier to prevent sodium back-leakage in distal colon. Differential expression of this gene has been observed in colorectal carcinoma and renal cell tumors, and along with claudin-7, is an immunohistochemical marker for the differential diagnosis of chromophobe renal cell carcinoma and renal oncocytoma.[provided by RefSeq, May 2010]

CLDN8 Products (1)

mRNA Protein Name
NM_199328.3 NP_955360.1 claudin-8

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CLDN8 Protein Structure

PMP22_Claudin

PMP22_Claudin: PMP-22/EMP/MP20/Claudin family (6 - 182)

  • 0
  • 100
  • 200
  • 225 a.a.
Protein Preferred Names Protein Names

claudin-8

  • epididymis secretory protein Li 79

CLDN8 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
CLDN8 P56748 ARL13B Homo sapiens Q3SXY8
Y2H Array
32296183
Intra
CLDN8 P56748 ARL13B Homo sapiens Q3SXY8
Y2H Prey Pooling
32296183
Intra
CLDN8 P56748 ARL13B Homo sapiens Q3SXY8
Validated Y2H
32296183
Intra
CLDN8 P56748 TMEM80 Homo sapiens Q96HE8
Y2H Array
32296183
Intra
CLDN8 P56748 TMEM80 Homo sapiens Q96HE8
Y2H Prey Pooling
32296183
Intra
CLDN8 P56748 TMEM80 Homo sapiens Q96HE8
Validated Y2H
32296183
Intra
CLDN8 P56748 CLEC17A Homo sapiens Q6ZS10
Validated Y2H
32296183
Intra
CLDN8 P56748 CLEC17A Homo sapiens Q6ZS10
Y2H Array
32296183
Intra
CLDN8 P56748 CLEC17A Homo sapiens Q6ZS10
Y2H Prey Pooling
32296183
Intra
CLDN8 P56748 PKMYT1 Homo sapiens Q99640-2
Validated Y2H
32296183
Intra
CLDN8 P56748 OPRM1 Homo sapiens P35372-10
Y2H Prey Pooling
32296183
Intra
CLDN8 P56748 OPRM1 Homo sapiens P35372-10
Y2H Array
32296183
Intra
CLDN8 P56748 ADAM32 Homo sapiens Q8TC27
Y2H Prey Pooling
32296183
Intra
CLDN8 P56748 ADAM32 Homo sapiens Q8TC27
Validated Y2H
32296183
Intra
CLDN8 P56748 ADAM32 Homo sapiens Q8TC27
Y2H Array
32296183
Intra
CLDN8 P56748 SYNE4 Homo sapiens Q8N205
Y2H Array
25416956
Intra
CLDN8 P56748 SMIM3 Homo sapiens Q9BZL3
Y2H Prey Pooling
32296183
Intra
CLDN8 P56748 SMIM3 Homo sapiens Q9BZL3
Validated Y2H
32296183
Intra
CLDN8 P56748 SMIM3 Homo sapiens Q9BZL3
Y2H Array
32296183
Intra
CLDN8 P56748 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra
CLDN8 P56748 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra
CLDN8 P56748 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

CLDN8 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81424 Claudin 8 Antibody (YA1169) IHC-P Human
HY-P81424A Claudin 8 Antibody (YA1169)(PBS only) IHC-P Human

Related Diseases

Diseases Alias
Renal Oncocytoma

  • Oncocytoma, Renal

  • Oncocytoma Of Kidney

  • Renal Epithelial Oncocytic Tumor

  • Oncocytoma Kidney

  • Oncocytoma Renal

  • Kidney Oncocytoma
Oncocytoma

  • Oxyphilic Adenoma

  • Follicular Adenoma, Oxyphilic Cell

  • Adenoma, Oxyphilic

  • Hurthle Cell Tumor

  • Oncocytic Neoplasm
Chromophobe Renal Cell Carcinoma

  • Chromophobe Adenocarcinoma

  • Chromophobe Carcinoma Of Kidney

  • Kidney Chromophobe

  • Renal Cell Carcinoma, Chromophobe Cell

  • Crcc

  • Chrcc

  • Chromophobe Renal Cell Adenocarcinoma

  • Chromophobe Renal Carcinoma

  • Chromophobe Carcinoma
Pseudohypoaldosteronism
Acute Salpingitis
Deafness, Autosomal Recessive 29

  • DFNB29

  • Autosomal Recessive Nonsyndromic Deafness 29

  • Autosomal Recessive Deafness 29

  • Deafness, Autosomal Recessive, 29

  • Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 29

  • Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 29

  • Deafness, Autosomal Recessive, Type 29
Renal Cell Carcinoma, Nonpapillary

  • Renal Cell Carcinoma

  • RCC

  • Nonpapillary Renal Cell Carcinoma

  • Clear Cell Renal Cell Carcinoma

  • Hypernephroma

  • Adenocarcinoma Of Kidney

  • Renal Carcinoma, Chromophobe, Somatic

  • Clear Cell Carcinoma Of Kidney

  • Clear-Cell Metastatic Renal Cell Carcinoma

  • Clear Cell Renal Carcinoma

  • Renal Cell Carcinoma, Somatic

  • Conventional Renal Cell Carcinoma

  • Conventional Renal Cell Carcinoma

  • Renal Clear Cell Carcinoma

  • Ccrcc

  • Hereditary Clear Cell Renal Cell Carcinoma

  • Carcinoma, Renal Cell

  • Renal Cell Carcinoma, Clear Cell, Somatic

  • Renal Cell Carcinoma, Clear Cell

  • Clear Cell Kidney Carcinoma

  • Clear Cell Rcc

  • Cystic-Multilocular Variant

  • Clear Cell Renal Cell Adenocarcinoma

  • Hereditary Clear Cell Renal Cell Adenocarcinoma

  • Common Renal Cell Carcinoma

  • Crcc

  • Renal Cell Carcinoma Non-Papillary

  • Carcinoma Renal Cell

  • Renal Cell Cancer

  • Carcinoma, Renal Cell, Nonpapillary
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS02776 CLDN8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22445 Cldn8 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS28968 Cldn8 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P990217 Anti-Mouse IL-23 p19 Antibody (G23-8) Inhibitor 99.14% Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus CLDN8 MGD MGI:1859286
Felis catus CLDN8 VGNC VGNC:102673
Macaca mulatta CLDN8 VGNC VGNC:81289
Bos taurus CLDN8 VGNC VGNC:27419
Rattus norvegicus CLDN8 RGD RGD:1308575
Canis familiaris CLDN8 VGNC VGNC:53023
Others CLDN8 NCBI