Claudin 8 Antibody (YA1169)(PBS only)

Cat. No.: HY-P81424A: Data Sheet User Guide for Antibodies
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Claudin 8 Antibody (YA1169) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Claudin 8.

For research use only. We do not sell to patients.

Size		Stock
50 μL		Get quote
100 μL		Get quote

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WB: Western Blot;
IHC-P: Immunohistochemistry-Paraffin;
IHC-F: Immunohistochemistry-Frozen;
ICC/IF: Immunocytochemistry/Immunofluorescence;
IF-Tissue: Immunofluorescence-Tissue;
mIHC: Multiplex Immunohistochemical;
IP: Immunoprecipitation;
ChIP: Chromatin Immunoprecipitation;
FC: Flow Cytometry;
ELISA: Enzyme Linked Immunosorbent Assay

Product Detail
Background
Documentation

Description

Claudin 8 Antibody (YA1169) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Claudin 8.

Host

Rabbit

Molecular Weight

Predicted band size: 28 kDa;

Observed band size: 28 kDa

Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.

Species Reactivity

Human

SwissProt ID

P56748

Gene ID

9073 [NCBI]

Immunogen

A synthesized peptide derived from human Claudin 8

Application &
Dilution Ratio

Application	Dilution Ratio
IHC-P IHC-P: Immunohistochemistry-Paraffin	1:100-1:200

Purity	Affinity Purified	Conjugation	Non-conjugated
Isotype	IgG

Appearance

Liquid

Formulation

Supplied in PBS, pH 7.4.

Storage & Stability

Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.

Shipping

Shipping with blue ice.

Background

Function：Can associate with other claudins to regulate tight junction structural and functional strand dynamics (By similarity). May coassemble with CLDN4 into tight junction strands containing anion-selective channels that convey paracellular chloride permeability in renal collecting ducts (By similarity) (PubMed:36008380). Cannot form tight junction strands on its own (PubMed:36008380)

Subcellular Localization：Cell junction, tight junction; Cell membrane; Multi-pass membrane protein

Expression：
Tissue_specificity:Expressed in the epididymis, mainly in the caput segment

Subunit：Can form heteropolymeric strands with other claudins (PubMed:36008380). Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3. Interacts with CLDN4; forms coassem. Interacts with KLHL3

Research Field

Signal Transduction

Synonyms

CLDN8; UNQ779/PRO1573 ; Claudin-8

Documentation

User Guide for Antibodies (1077 KB)