Ror
ROR1 and ROR2 define the Ror branch of receptor tyrosine kinases, distinguished by an extracellular array of a cysteine-rich Wnt-binding Frizzled domain, two immunoglobulin-like domains, and a kringle domain. Acting as Wnt5a receptors, they drive non-canonical planar cell polarity, calcium, and Rho-GTPase signaling that governs limb, craniofacial, cardiac, and skeletal development; ROR2 loss-of-function causes Robinow syndrome, and ROR1 variants are linked to brachydactyly type B2. On malignant B cells and many solid tumors, ROR1 reappears as a pro-survival and migration receptor, fueling CAR-T, bispecific, and antibody-drug conjugate programs. Recombinant Ror ectodomains support Wnt-binding studies.
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Ror Recombinant Proteins (4)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
