5-MCA-NAT
5-MCA-NAT is a melatonin agonist that may target the melatoninMT3 receptor. 5-MCA-NAT can contract the colonic band in a concentration-dependent manner and reduce intraocular pressure (IOP) in glaucomatous monkey eyes, inhibiting the increase in IOP.
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- CAS No.: 190277-13-5
- Formule: C14H17N3O3
- Masse moléculaire:275.30
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Melatonin MT3 receptor[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
100 nM
Compound: MCA-NAT
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Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells
Displacement of 2-[125I]iodomelatonin from human MT1 receptor expressed in HEK293 cells
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[PMID: 18372181] |
| HEK293 | IC50 |
4 μM
Compound: MCA-NAT
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Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cells
Displacement of 2-[125I]iodomelatonin from human MT2 receptor expressed in HEK293 cells
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[PMID: 18372181] |
Chemical Information
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CAS No. 190277-13-5
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Masse moléculaire 275.30
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Formule C14H17N3O3
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SMILES
O=C(NC1=CC2=C(NC=C2CCNC(C)=O)C=C1)OC
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Lucchelli A, et al. Investigation into the contractile response of melatonin in the guinea-pig isolated proximal colon: the role of 5-HT4 and melatonin receptors. Br J Pharmacol. 1997 Aug;121(8):1775-81. [Content Brief]
[2]. Serle JB, et al. Effect of 5-MCA-NAT, a putative melatonin MT3 receptor agonist, on intraocular pressure in glaucomatous monkey eyes. J Glaucoma. 2004 Oct;13(5):385-8. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
5-MCA-NAT Related Classifications
HY-101303 Related Classifications
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