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Amitifadine

(Synonyms: DOV-21947; EB-1010)

Amitifadine (DOV-21947; EB-1010) is a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI), with IC₅₀s of 12, 23, 96 nM for serotonin, norepinephrine and dopamine in HEK 293 cells , respectively.

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CAS No.: 410074-73-6
Formule: C₁₁H₁₁Cl₂N
Masse moléculaire:228.12

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

Amitifadine Chemical Structure

CAS No.: 410074-73-6

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
Chemical Information
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Références
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Activité biologique

Description

Voir tous les produits spécifiques à Isoform Dopamine Receptor :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	10 μM Compound: 4, DOV-21947	Inhibition of human ERG expressed in CHO cells Inhibition of human ERG expressed in CHO cells	[PMID: 18954985]
CHO	IC₅₀	93.8 nM Compound: 5, DOV-216303	Inhibition of dopamine reuptake at human dopamine transporter expressed in CHO cells Inhibition of dopamine reuptake at human dopamine transporter expressed in CHO cells	[PMID: 20724153]
HEK293	IC₅₀	215 nM Compound: 5, DOV-216303	Inhibition of serotonin reuptake at human SERT expressed in HEK293 cells Inhibition of serotonin reuptake at human SERT expressed in HEK293 cells	[PMID: 20724153]
HEK293	IC₅₀	143 nM Compound: DOV216,303	Inhibition of norepinephrine reuptake at human NET expressed in HEK293 cells after 15 mins by fluorescence neurotransmitter transporter assay Inhibition of norepinephrine reuptake at human NET expressed in HEK293 cells after 15 mins by fluorescence neurotransmitter transporter assay	[PMID: 24974340]
HEK293	IC₅₀	394 nM Compound: DOV216,303	Inhibition of DA reuptake at human DAT expressed in HEK293 cells after 15 mins by fluorescence neurotransmitter transporter assay Inhibition of DA reuptake at human DAT expressed in HEK293 cells after 15 mins by fluorescence neurotransmitter transporter assay	[PMID: 24974340]
HEK293	IC₅₀	723 nM Compound: DOV216,303	Inhibition of serotonin reuptake at human SERT expressed in HEK293 cells after 15 mins by fluorescence neurotransmitter transporter assay Inhibition of serotonin reuptake at human SERT expressed in HEK293 cells after 15 mins by fluorescence neurotransmitter transporter assay	[PMID: 24974340]
HEK293	IC₅₀	159.3 nM Compound: DOV21947	Inhibition of [3H]-DA uptake in human dopamine transporter expressed in HEK293 cells by scintillation counting Inhibition of [3H]-DA uptake in human dopamine transporter expressed in HEK293 cells by scintillation counting	[PMID: 25164761]
HEK293	IC₅₀	411.5 nM Compound: DOV21947	Inhibition of [3H]-serotonin uptake in human SERT expressed in HEK293 cells by scintillation counting Inhibition of [3H]-serotonin uptake in human SERT expressed in HEK293 cells by scintillation counting	[PMID: 25164761]
HEK293	IC₅₀	71.4 nM Compound: DOV21947	Inhibition of [3H]-NE uptake in human norepinephrine transporter expressed in HEK293 cells by scintillation counting Inhibition of [3H]-NE uptake in human norepinephrine transporter expressed in HEK293 cells by scintillation counting	[PMID: 25164761]
MDCK	IC₅₀	72.4 nM Compound: 5, DOV-216303	Inhibition of norepinephrine reuptake at human NET expressed in MDCK cells Inhibition of norepinephrine reuptake at human NET expressed in MDCK cells	[PMID: 20724153]

Chemical Information

CAS No. 410074-73-6
Masse moléculaire 228.12
Formule C₁₁H₁₁Cl₂N
SMILES

ClC1=C(Cl)C=CC([C@]23[C@](CNC3)([H])C2)=C1
Synonyms

DOV-21947; EB-1010
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Skolnick P1, et al. Antidepressant-like actions of DOV 21,947: a "triple" reuptake inhibitor. Eur J Pharmacol. 2003 Feb 14;461(2-3):99-104. [Content Brief]

[2]. Levin ED, et al. Amitifadine, a triple monoamine re-uptake inhibitor, reduces nicotine self-administration in female rats. Eur J Pharmacol. 2015 Jun 20;764:30-37. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
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Chemical Information
Pureté et documentation
Références

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