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Cat. No.: HY-143326

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Antibacterial agent 83

Antibacterial agent 83 (compound 17h) displays potent antibacterial activity against various vancomycin-resistant Enterococcus faecalis (VRE) and methicillin-resistant Staphylococcus aureus (MRSA). Antibacterial agent 83 can significantly reduce the biofilm formation of MRSA and exhibited promising selectivity. Antibacterial agent 83 is metabolically stable in human liver microsomes.

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CAS No.: 2413865-92-4
Formule: C₁₁H₅Cl₂N₃O₂
Masse moléculaire:282.08

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Antibacterial agent 83 Chemical Structure

CAS No.: 2413865-92-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
- In Vitro
Chemical Information
Pureté et documentation
Références
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Activité biologique

Description

Cellular Effect

Cell Line	Type	Value	Description	References
L02	IC₅₀	10.7 μM Compound: 17h	Cytotoxicity against human L02 cells after 72 hrs by CCK-8 assay Cytotoxicity against human L02 cells after 72 hrs by CCK-8 assay	[PMID: 35398730]
L02	IC₅₀	3.02 μg/mL Compound: 17h	Cytotoxicity against human L02 cells after 72 hrs by CCK-8 assay Cytotoxicity against human L02 cells after 72 hrs by CCK-8 assay	[PMID: 35398730]

In Vitro

Antibacterial agent 83 (compound 17h) shows antibacterial activity against Newmana, USA300b, and Mu50, with MIC of 0.25 μg/mL all^[1].
Antibacterial agent 83 performs poor stability in the liver microsomes of rat, mouse and dog^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

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Chemical Information

CAS No. 2413865-92-4
Masse moléculaire 282.08
Formule C₁₁H₅Cl₂N₃O₂
SMILES

N#CC1=NNC(C(C2=C(C=C(C(Cl)=C2)Cl)O)=O)=C1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Huan X, et al. Design, synthesis, and biological evaluations of substituted pyrazoles as pyrrolomycin analogues against staphylococcal biofilm. Eur J Med Chem. 2022 Jun 5;236:114309. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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