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Cat. No.: HY-149231

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Anticancer agent 104

Anticancer agent 104 has anticancer activity, and induces cancer cell apoptosis.

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CAS No.: 3047612-51-8
Formule: C₃₄H₄₇F₃N₂O₂S₂
Masse moléculaire:636.87

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (274 KB)

Anticancer agent 104 Chemical Structure

CAS No.: 3047612-51-8

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Anticancer agent 104 has anticancer activity, and induces cancer cell apoptosis^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
786-0	IC₅₀	91.67 μM Compound: 4l	Anticancer activity against human 786-0 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Anticancer activity against human 786-0 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 37084600]
Calu-1	IC₅₀	78.34 μM Compound: 4l	Anticancer activity against human Calu-1 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Anticancer activity against human Calu-1 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 37084600]
HEK-293T	IC₅₀	195.17 μM Compound: 4l	Cytotoxicity against human HEK293T cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human HEK293T cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 37084600]
HepG2	IC₅₀	31.39 μM Compound: 4l	Anticancer activity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Anticancer activity against human HepG2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 37084600]
Huh-7	IC₅₀	75.18 μM Compound: 4l	Anticancer activity against human Huh-7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Anticancer activity against human Huh-7 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 37084600]
KGN	IC₅₀	176.38 μM Compound: 4l	Cytotoxicity against human KGN cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human KGN cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 37084600]
LX-2	IC₅₀	96.33 μM Compound: 4l	Cytotoxicity against human LX2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human LX2 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 37084600]
MCF-10A	IC₅₀	21.06 μM Compound: 4l	Cytotoxicity against human MCF-10A cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human MCF-10A cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 37084600]
SK-BR-3	IC₅₀	44.18 μM Compound: 4l	Anticancer activity against human SK-BR-3 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Anticancer activity against human SK-BR-3 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 37084600]
SK-OV-3	IC₅₀	112.19 μM Compound: 4l	Anticancer activity against human SK-OV-3 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Anticancer activity against human SK-OV-3 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 37084600]
WI-38	IC₅₀	81.48 μM Compound: 4l	Cytotoxicity against human WI-38 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay Cytotoxicity against human WI-38 cells assessed as reduction in cell viability incubated for 48 hrs by MTT assay	[PMID: 37084600]

In Vitro

Anticancer agent 104 (Compound 4l) (48 h) is toxic to HepG2 cells (IC₅₀: 31.39 μM)^[1].
Anticancer agent 104 (10-200 μg/mL, 48 h) exhibits volume reduction, chromatin margination, and eventually formed apoptotic vesicles^[1].
Anticancer agent 104 (10-100 μg/mL, 48 h) induces HepG2 cell apoptosis^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

Calu-1, SK-BR-3, HUH-7, 786-O, SK-OV-3 cells
Concentration:

0-200 μM approximately
Incubation Time:

48 h
Result:

Shows cytotoxic activities with IC₅₀s of 78.34, 44.18, 75.18, 91.67, 112.19 μM.

Apoptosis Analysis^[1]

Cell Line:

HepG2 cells
Concentration:

10, 50 and 100 μg/mL
Incubation Time:

48 h
Result:

Showed apoptotic rate of 23.67%, 41.21% and 61.16% respectively.

Related Protocols :

Chemical Information

CAS No. 3047612-51-8
Masse moléculaire 636.87
Formule C₃₄H₄₇F₃N₂O₂S₂
SMILES

C[C@@]1(C(C)([C@@](CC1)([H])C2)C)[C@@H]2OC(CCC[C@@H]3[C@]4([H])[C@]5([H])[C@](CCCN5CCC4)([H])CN3C(SCC6=CC=C(C=C6)C(F)(F)F)=S)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (274 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Zhang MW, et al. Design, synthesis and biological evaluation of matrine-dithiocarbamate hybrids as potential anticancer agents. Eur J Med Chem. 2023 Jun 5;254:115375. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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100 mg

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