Anticancer agent 106
Anticancer agent 106 (compound 10ic) is an anticancer agent that induces apoptosis in B16-F10 melanoma cells. Anticancer agent 106 also potently inhibits metastatic nodules in a mouse model of lung metastatic melanoma. Anticancer agent 106 can be used in the study of cancer, especially lung metastatic melanoma.
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- CAS No.: 3009090-13-2
- Formule: C26H25N3O4S
- Masse moléculaire:475.56
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Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
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Help & FAQs
Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| 4T1 | IC50 |
6.5 μM
Compound: 10ic
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Cytotoxicity against mouse 4T1 cells assessed as cell survival incubated for 24 hrs by alamarblue staining based analysis
Cytotoxicity against mouse 4T1 cells assessed as cell survival incubated for 24 hrs by alamarblue staining based analysis
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[PMID: 37084598] |
| B16-F10 | IC50 |
4.8 μM
Compound: 10ic
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Cytotoxicity against mouse B16-F10 cells assessed as cell survival incubated for 24 hrs by alamarblue staining based analysis
Cytotoxicity against mouse B16-F10 cells assessed as cell survival incubated for 24 hrs by alamarblue staining based analysis
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[PMID: 37084598] |
| CT26 | IC50 |
7.4 μM
Compound: 10ic
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Cytotoxicity against mouse CT26 cells assessed as cell survival incubated for 24 hrs by alamarblue staining based analysis
Cytotoxicity against mouse CT26 cells assessed as cell survival incubated for 24 hrs by alamarblue staining based analysis
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[PMID: 37084598] |
| MEF | IC50 |
>100 μM
Compound: 10ic
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Cytotoxicity against NF2-deficient mouse MEF cells assessed as cell survival incubated for 24 hrs by alamarblue staining based analysis
Cytotoxicity against NF2-deficient mouse MEF cells assessed as cell survival incubated for 24 hrs by alamarblue staining based analysis
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[PMID: 37084598] |
Anticancer agent 106 (compound 10ic; 0.28-55 μM; 24 h) reduces the viability of B16-F10 melanoma cells in a dose-dependent manner, with an IC50 value of 4.8 μM[1].
Anticancer agent 106 (5-20 μM; 48 h) induces apoptosis of B16-F10 melanoma cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:B16-F10 melanoma cells
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Concentration:0.28-55 μM
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Incubation Time:24 h
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Result:Inhibited B16-F10 melanoma cells in a dose-dependent manner (IC50 = 4.8 μM).
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Cell Line:B16-F10 melanoma cells
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Concentration:5-20 μM
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Incubation Time:48 h
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Result:Induced cell apoptosis.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:B16-F10 melanoma-bearing C57BL/6 mice (pulmonary metastatic melanoma model)[1].
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Dosage:9-9.5 mg/kg
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Administration:Intraperitoneal administration; every 3rd d for 22 d.
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Result:Inhibited the lung metastases.
Chemical Information
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CAS No. 3009090-13-2
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Masse moléculaire 475.56
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Formule C26H25N3O4S
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SMILES
N#CC1=C(N)N(C2=C(C(OCC)=O)C(CCCCC3)=C3S2)/C(C1=O)=C/C(C4=CC=C(C)C=C4)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anticancer agent 106 Related Classifications
HY-149950 Related Classifications
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