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Cat. No.: HY-138627

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AST5902

AST5902 is the active metabolite of Furmonertinib (HY-112870) with antitumor activity, and acts as a EGFR inhibitor. AST5902 inhibits CYP3A4 mRNA transcription at low concentrations and induces CYP3A4 mRNA expression at high concentrations. AST5902 can be used in research related to non-small cell lung cancer.

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CAS No.: 2412155-74-7
Formule: C₂₇H₂₉F₃N₈O₂
Masse moléculaire:554.57

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (290 KB)

AST5902 Chemical Structure

CAS No.: 2412155-74-7

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Description

IC₅₀ & Target

CYP3A4

EGFR

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In Vitro

AST5902 exhibits anti-tumor activity comparable to that of its parent compound Furmonertinib (HY-112870), a potent EGFR inhibitor.^[1]
AST5902 is generated via CYP3A4-mediated N-demethylation of Furmonertinib in human liver microsomes^[2].
AST5902 (0.003‑5 μM) modulates CYP3A4 mRNA expression in primary human hepatocytes, exhibiting weak to moderate CYP3A4 induction activity with an EC₅₀ ranging from 0.13‑0.68 μM, and inhibits CYP3A4 mRNA transcription at low concentrations^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2412155-74-7
Masse moléculaire 554.57
Formule C₂₇H₂₉F₃N₈O₂
SMILES

C=CC(NC1=CC(NC2=NC=CC(C3=CN(C)C4=C3C=CC=C4)=N2)=C(OCC(F)(F)F)N=C1N(C)CCNC)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (290 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Zou HX, et al. Effect of autoinduction and food on the pharmacokinetics of furmonertinib and its active metabolite characterized by a population pharmacokinetic model. Acta pharmacologica Sinica. 2022 Jul;43(7):1865-1874.

[2]. Liu XY, et al. Alflutinib (AST2818), primarily metabolized by CYP3A4, is a potent CYP3A4 inducer. Acta pharmacologica Sinica. 2020 Oct;41(10):1366-1376. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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AST5902

Voir tous les produits spécifiques à Isoform EGFR

Voir tous les produits spécifiques à Isoform Cytochrome P450

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