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Cat. No.: HY-146183

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BCL6-IN-9

BCL6-IN-9 (compound 1) is a potent B-cell lymphoma 6 protein (BCL6) inhibitor, with an IC₅₀ of 3.9 nM. BCL6-IN-9 can be used for the research of cancer.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 2378852-76-5
Formule: C₂₂H₁₈ClF₂N₅O₂
Masse moléculaire:457.86

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

BCL6-IN-9 Chemical Structure

CAS No.: 2378852-76-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

BCL6-IN-9 (compound 1) is a potent B-cell lymphoma 6 protein (BCL6) inhibitor, with an IC₅₀ of 3.9 nM. BCL6-IN-9 can be used for the research of cancer^[1].

IC₅₀ & Target

IC50: 3.9 nM (B-cell lymphoma 6 protein)^[1]

Voir tous les produits spécifiques à Isoform Bcl-2 Family :

Cellular Effect

Cell Line	Type	Value	Description	References
KARPAS-422	GI₅₀	0.19 μM Compound: 1	Antiproliferative activity against human KARPAS-422 cells assessed as cell growth inhibition mesured after 14 days by CellTiter-Glo luminescent assay Antiproliferative activity against human KARPAS-422 cells assessed as cell growth inhibition mesured after 14 days by CellTiter-Glo luminescent assay	[PMID: 35657291]
OCI-Ly1	GI₅₀	0.17 μM Compound: 1	Antiproliferative activity against human OCI-Ly1 cells assessed as cell growth inhibition mesured after 14 days by CellTiter-Glo luminescent assay Antiproliferative activity against human OCI-Ly1 cells assessed as cell growth inhibition mesured after 14 days by CellTiter-Glo luminescent assay	[PMID: 35657291]
OCI-Ly3	GI₅₀	3.4 μM Compound: 1	Antiproliferative activity against human OCILY3 cells assessed as cell growth inhibition mesured after 14 days by CellTiter-Glo luminescent assay Antiproliferative activity against human OCILY3 cells assessed as cell growth inhibition mesured after 14 days by CellTiter-Glo luminescent assay	[PMID: 35657291]

Chemical Information

CAS No. 2378852-76-5
Masse moléculaire 457.86
Formule C₂₂H₁₈ClF₂N₅O₂
SMILES

N#CC1=C(NC2=CC3=C(N(C)C(C4=C3N[C@@H](C5CC5)C(F)(F)CO4)=O)C=C2)C=CN=C1Cl
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Davis OA, et, al. Optimizing Shape Complementarity Enables the Discovery of Potent Tricyclic BCL6 Inhibitors. J Med Chem. 2022 Jun 3. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

MOQ

Minimum order quantity

100 mg

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Activité biologique
- Description
- IC₅₀ & Target
Chemical Information
Pureté et documentation
Références

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BCL6-IN-9

Voir tous les produits spécifiques à Isoform Bcl-2 Family

Activité biologique

Description

IC50 & Target

Cellular Effect

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

BCL6-IN-9 Related Classifications

HY-146183 Related Classifications

Bioz

Keywords

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