Bis-PEG5-NHS ester
Based on 1 Customer Validation
Bis-PEG5-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG5-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs).
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- Pureté: 99.89%
- CAS No.: 756526-03-1
- Formule: C22H32N2O13
- Masse moléculaire:532.50
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Stockage:
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Voir tous les produits spécifiques à Isoform ADC Linkers
MoreVoir tous les produits spécifiques à Isoform PROTAC Linkers
More
Activité biologique
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Cleavable Linker |
PEGs |
Alkyl/ether |
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 756526-03-1
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Appearance Solid-Liquid Mixture
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Masse moléculaire 532.50
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Formule C22H32N2O13
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Color Colorless to off-white
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SMILES
O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCOCCOCCC(ON2C(CCC2=O)=O)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
-20°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Solvant et solubilité
DMSO : 100 mg/mL (187.79 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (267 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.8779 mL | 9.3897 mL | 18.7793 mL | 46.9484 mL |
| 5 mM | 0.3756 mL | 1.8779 mL | 3.7559 mL | 9.3897 mL | |
| 10 mM | 0.1878 mL | 0.9390 mL | 1.8779 mL | 4.6948 mL | |
| 15 mM | 0.1252 mL | 0.6260 mL | 1.2520 mL | 3.1299 mL | |
| 20 mM | 0.0939 mL | 0.4695 mL | 0.9390 mL | 2.3474 mL | |
| 25 mM | 0.0751 mL | 0.3756 mL | 0.7512 mL | 1.8779 mL | |
| 30 mM | 0.0626 mL | 0.3130 mL | 0.6260 mL | 1.5649 mL | |
| 40 mM | 0.0469 mL | 0.2347 mL | 0.4695 mL | 1.1737 mL | |
| 50 mM | 0.0376 mL | 0.1878 mL | 0.3756 mL | 0.9390 mL | |
| 60 mM | 0.0313 mL | 0.1565 mL | 0.3130 mL | 0.7825 mL | |
| 80 mM | 0.0235 mL | 0.1174 mL | 0.2347 mL | 0.5869 mL | |
| 100 mM | 0.0188 mL | 0.0939 mL | 0.1878 mL | 0.4695 mL |
Bis-PEG5-NHS ester Related Classifications
HY-126889 Related Classifications
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