BMX-IN-4
BMX-IN-4 is a covalent BMX kinase inhibitor with an IC50 of 1.78 nM and a Ki of 0.158 μM. BMX-IN-4 forms a covalent bond with BMX kinase. BMX-IN-4 is applicable to the research of hepatocellular carcinoma.
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- CAS No.: 3132799-96-0
- Formule: C21H15ClN4O2S
- Masse moléculaire:422.89
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
BMX-IN-4 (Compound 11i) potently inhibits recombinant BMX with an IC50 of 1.78 nM; it exhibits 2.3-fold selectivity over recombinant BTK, and its activity is dependent on a covalent warhead[1].
BMX-IN-4 achieves selective cellular target binding to BMX but not BTK in HEK293T cells, with an EC50 of 0.098 μM against BMX and a selectivity window of 20.6-fold[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 3132799-96-0
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Masse moléculaire 422.89
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Formule C21H15ClN4O2S
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SMILES
O=C(NC1=CN=C(C2=C1)NC=C2C3=CC=CC(NC(C=C)=O)=C3)C4=CC=C(S4)Cl
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
BMX-IN-4 Related Classifications
HY-187351 Related Classifications
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