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Cat. No.: HY-P991674

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Brelovitug

Name: Brelovitug
Brand: MedChemExpress
SKU: HY-P991674
Price: 280.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: BJT-778)

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Based on 1 Customer Validation

Brelovitug (BJT-778) is a humanized IgG1 neutralizing monoclonal antibody targeting hepatitis B surface antigen (HBsAg). Brelovitug binds with high affinity to HBsAg purified from HBV serotypes ad and ay, with K_d values of 0.22 nM and 0.39 nM, respectively. Brelovitug binds with high affinity to HBsAg of HBV genotypes A, B, C and D, with IC₅₀ values of 0.07, 0.02, 0.02 and 0.07 nM, respectively. Brelovitug can be used in research related to chronic hepatitis B and chronic hepatitis D.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Pureté: 99%
CAS No.: 3033337-14-0
Masse moléculaire:143.954 kDa

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Brelovitug Chemical Structure

CAS No.: 3033337-14-0

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- In Vivo
- Conjugated
- Reconsititution
- Format
- Application
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Isotype

Human IgG1 lambda2

Recommend Isotype Controls

Human IgG1 lambda2, Isotype Control

Species Reactivity

Virus

IC₅₀ & Target

HbsAg

In Vitro

Brelovitug binds to wild-type and clinically mutated HBsAg (D144A, T126S, M133L) with IC₅₀ values ranging from 0.03 to 0.99 nM, but does not bind to HBsAg bearing the G145R mutation^[1].
Brelovitug (8 days) potently neutralizes HBV infection in primary human hepatocytes, with EC₅₀ values of 0.09 nM for HBsAg inhibition and 0.11 nM for HBeAg inhibition^[1].
Brelovitug (8 days) potently neutralizes HDV infection in HBV/HDV co-infected primary human hepatocytes, with an EC₅₀ value of 0.01 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

BJT-778 (20 mg/kg; i.p.; dosed on day 0 and day 21) rapidly depletes serum HBsAg and maintains depletion for up to 14 days in a humanized FRG mouse model of chronic HBV infection^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Fah/Rag2/IL-2rγ triple knockout (FRG) (humanized, chronic HBV infection model)^[1]
Dosage:

20 mg/kg
Administration:

i.p.; dosed on day 0 and day 21
Result:

Rapidly depleted serum HBsAg and maintained HBsAg depletion for up to 14 days post-dosing.

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

IgG1-lambda

Application

ELISA, FACS, Functional assay

Chemical Information

CAS No. 3033337-14-0
Appearance Liquid
Masse moléculaire 143.954 kDa
Color Colorless to light yellow
SMILES

N/A
Synonyms

BJT-778
Livraison

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (259 KB)
SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

Références

[1]. Ramos HJ, et al. Characterization of BJT-778, an anti-HBsAg neutralizing monoclonal antibody for treatment of hepatitis B virus and hepatitis D virus infections. InEASL Congress 2024 Jun 1 (pp. 5-8).

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

Activité biologique
- Description
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- In Vivo
- Conjugated
- Reconsititution
- Format
- Application
Chemical Information
Pureté et documentation
Références

Nom du produit:
Cat. No.:
Quantité:
MCE Japan Authorized Agent:

Nom du produit:
CAS No.:
Species:
Pureté:
Quantité:

Brelovitug

DPBS Buffer (1×)

Cytotoxicity LDH Assay Kit

PBS Buffer (1×)