Butyryltimolol
Based on 1 Customer Validation
Butyryltimolol, an effective precursor of Timolol, improves the corneal penetration of Timolol. Butyryltimolol is a β-adrenergic blocker.
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- Pureté : 98.0%
- CAS No.: 106351-79-5
- Formule: C17H30N4O4S
- Masse moléculaire:386.51
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Stockage:Pure form -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
Voir tous les produits spécifiques à Isoform Adrenergic Receptor
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Activité biologique
Description
IC50 & Target
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β adrenergic receptor |
In Vitro
Butyryltimolol, a prodrug of Timolol, is equally effective as 240-min nasolacrimal blockade in enhancing ocular drug absorption[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 106351-79-5
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Appearance Liquid (Density: 1.169±0.06 g/cm3)
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Masse moléculaire 386.51
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Formule C17H30N4O4S
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Color Colorless to light yellow
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SMILES
CCCC(O[C@@H](CNC(C)(C)C)COC1=NSN=C1N2CCOCC2)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Pure form -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
In Vitro:
DMSO : 100 mg/mL (258.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Pureté et documentation
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Fiche technique (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. Chang SC, et al. Relative effectiveness of prodrug and viscous solution approaches in maximizing the ratio of ocular to systemic absorption of topically applied timolol. Exp Eye Res. 1988 Jan;46(1):59-69. [Content Brief]
[2]. Potter DE, et al. Ocular and cardiac beta-antagonism by timolol prodrugs, timolol and levobunolol. Curr Eye Res. 1988 Aug;7(8):755-9. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.5873 mL | 12.9363 mL | 25.8726 mL | 64.6814 mL |
| 5 mM | 0.5175 mL | 2.5873 mL | 5.1745 mL | 12.9363 mL | |
| 10 mM | 0.2587 mL | 1.2936 mL | 2.5873 mL | 6.4681 mL | |
| 15 mM | 0.1725 mL | 0.8624 mL | 1.7248 mL | 4.3121 mL | |
| 20 mM | 0.1294 mL | 0.6468 mL | 1.2936 mL | 3.2341 mL | |
| 25 mM | 0.1035 mL | 0.5175 mL | 1.0349 mL | 2.5873 mL | |
| 30 mM | 0.0862 mL | 0.4312 mL | 0.8624 mL | 2.1560 mL | |
| 40 mM | 0.0647 mL | 0.3234 mL | 0.6468 mL | 1.6170 mL | |
| 50 mM | 0.0517 mL | 0.2587 mL | 0.5175 mL | 1.2936 mL | |
| 60 mM | 0.0431 mL | 0.2156 mL | 0.4312 mL | 1.0780 mL | |
| 80 mM | 0.0323 mL | 0.1617 mL | 0.3234 mL | 0.8085 mL | |
| 100 mM | 0.0259 mL | 0.1294 mL | 0.2587 mL | 0.6468 mL |
Butyryltimolol Related Classifications
HY-102032 Related Classifications
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