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Cat. No.: HY-183181

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CGRP antagonist-9

CGRP antagonist-9 is a CGRP receptor antagonist with an IC₅₀ of 25 nM. It regulates the cAMP signaling pathway and can be used in migraine-related studies.

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CAS No.: 1610413-84-7
Formule: C₄₀H₄₉N₉O₄S
Masse moléculaire:751.94

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

CGRP antagonist-9 Chemical Structure

CAS No.: 1610413-84-7

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- Cellular Effect
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
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Classifications
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Activité biologique

Description

CGRP antagonist-9 is a CGRP receptor antagonist with an IC₅₀ of 25 nM. It regulates the cAMP signaling pathway and can be used in migraine-related studies^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
SK-N-MC	EC₅₀	96 nM Compound: 7	Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of alpha-CGRP-induced c-AMP formation after 15 mins by radioimmunoassay Antagonist activity at CGRP receptor in human SK-N-MC cells assessed as inhibition of alpha-CGRP-induced c-AMP formation after 15 mins by radioimmunoassay	[PMID: 24794104]

In Vitro

CGRP antagonist-9 (Compound 7) antagonizes αCGRP-induced cAMP production in SK-N-MC cells with an EC₅₀ of 96 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1610413-84-7
Masse moléculaire 751.94
Formule C₄₀H₄₉N₉O₄S
SMILES

O=C1N(C2CCN(CC2)C(N[C@@H](C(N[C@@H](CCCCN)C(N3CCN(C4=CC=NC=C4)CC3)=O)=O)CC5=CC6=CC=CC=C6S5)=O)CC7=CC=CC=C7N1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Dasgupta B, et al. Serendipitous oxidation product of BIBN4096BS: a potent CGRP receptor antagonist. Bioorg Med Chem Lett. 2014;24(12):2744-2748. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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