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Cat. No.: HY-151615

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DCI-Br-3

DCI-Br-3 is a rapid, highly sensitive, and selective probe to monitor thiols in the epileptic brain. (λ_ex=537 nm, λ_em=675 nm).DCI-Br-3 can effectively cross the blood-brain barrier (BBB).

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

Formule: C₂₅H₂₀BrN₃O₂
Masse moléculaire:474.35

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

DCI-Br-3 Chemical Structure

Stock

Quantité

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
- In Vivo
- Emission (Em)
- Excitation (Ex)
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

DCI-Br-3 is a rapid, highly sensitive, and selective probe to monitor thiols in the epileptic brain. (λ_ex=537 nm, λ_em=675 nm).DCI-Br-3 can effectively cross the blood-brain barrier (BBB)^[1].

In Vitro

DCI-Br-3 (0-20 μM; 30 min; SH-SY5Y cells) increases intracellular fluorescence in a concentration-dependent manner and has a good response to thiols in SH-SY5Y cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

DCI-Br-3 (5 mg/kg; i.p.; BALB/c mice) effectively crosses the blood-brain barrier and help monitor the decrease of thiols in the brain^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c mice (6 weeks of age)^[1]
Dosage:

5 mg/kg
Administration:

intraperitoneal injection
Result:

Crossed the blood−brain barrier and had red fluorescence in BALB/c mice.

Emission (Em)

675

Excitation (Ex)

537

Chemical Information

Masse moléculaire 474.35
Formule C₂₅H₂₀BrN₃O₂
SMILES

N#C/C(C#N)=C1CC(C)(C)CC(/C=C/C2=CC=C(OC(C3=CC=NC=C3)=O)C(Br)=C2)=C\1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Yang Y, et, al. Synergistic Modulation by Halogens and Pyridine Crossing the Blood-Brain Barrier for InSitu Visualization of Thiol Flux in the Epileptic Brain. Anal Chem. 2022 Oct 18;94(41):14443-14452. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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