country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

Cat. No.: HY-108029

Copy Link Print Information

Deldeprevir sodium

Name: Deldeprevir sodium
Brand: MedChemExpress
SKU: HY-108029
Availability: PreOrder

(Synonyms: ACH-2684 sodium; Neceprevir sodium)

Deldeprevir (ACH-2684; Neceprevir) sodium is a HCV NS3/4A protease inhibitor and resistance inhibitor. Deldeprevir sodium exhibits activity against wild-type genotype 1a and 1b HCV, including mutant strains resistant to other NS3 protease inhibitors. Deldeprevir sodium blocks the emergence of HCV mutant strains resistant to ACH-3422 in vitro, with enhanced efficacy when used in triple combination with ACH-3422 and ACH-3102 (HY-124182). Deldeprevir sodium shows additive antiviral potency when combined with ACH-3422, and exerts antiviral activity against HCV replicons carrying ACH-3102. Deldeprevir sodium is applicable to research related to hepatitis C.

Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.

CAS No.: 1298053-61-8
Formule: C₄₅H₅₅F₂N₆NaO₈S₂
Masse moléculaire:933.07

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (280 KB)

Deldeprevir sodium Chemical Structure

CAS No.: 1298053-61-8

Size

Prix

Stock

Quantité

Amount: USD 0.00

* Veuillez sélectionner la quantité avant d'ajouter des articles.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

In Vitro

Deldeprevir sodium (3 days; antiviral combination study) exhibits higher in vitro potency against genotype-1a and 1b HCV replicons than BMS-032, and its combination with ACH-3102 reduces the emergence of resistance variants in these replicon cell lines^[1].
ACH-2684 (Deldeprevir sodium) (3 days) exhibits higher in vitro potency against genotype 1a and 1b HCV replicons than a reference NS3 protease inhibitor, and displays additive or synergistic antiviral efficacy when combined with a HCV NS5A inhibitor while reducing resistance variant emergence^[2].
Combining Deldeprevir sodium with the NS5B nucleotide inhibitor ACH-3422, or with ACH-3422 plus the NS5A inhibitor ACH-3102, enhances antiviral activity and blocks the emergence of ACH-3422-resistant HCV replicons in vitro^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Research Protocol for Infectious Diseases

Chemical Information

CAS No. 1298053-61-8
Masse moléculaire 933.07
Formule C₄₅H₅₅F₂N₆NaO₈S₂
SMILES

O=C([C@]([C@]1([H])/C=C\CCCCC[C@@H]2CC(N3CC(F)(F)CCC3)=O)(C1)NC([C@@](C[C@@H](OC4=CC(C5=NC(C(C)C)=CS5)=NC6=C(C)C(OC)=CC=C46)C7)([H])N7C2=O)=O)N([Na])S(=O)(C8CC8)=O
Synonyms

ACH-2684 sodium; Neceprevir sodium
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (280 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Zhao Y, et al. In VitroStudies Demonstrate a High Probability of Curing Genotype-1 Hepatitis C Patients with Combination of a Novel NS3 Protease Inhibitor ACH-2684 and a Novel NS5A Inhibitor ACH-3102: 1886[J]. Hepatology, 2012, 56: 1071A-1072A.

[2]. Baglino S L, et al. Pegylated Interferons Lambda-1a and Alfa-2a Display Different Gene Induction and Cytokine Release Profiles in Both Human Hepatocytes and Peripheral Blood Mononuclear Cells: 1885[J]. Hepatology, 2012, 56: 1071A.

[3]. Zhou X J, et al. Pharmacokinetics and Drug-Drug Interaction between Samatasvir, an NS5A Inhibitor, and Co-administered Simeprevir, an NS3/4A Protease Inhibitor, and Low Dose Ritonavir-Boosted TMC647055, a Non-Nucleoside NS5B Inhibitor, in Healthy Volunteers and HCV-Infected Subjects: 1987[J]. Hepatology, 2014, 60: 1167A-1168A.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

Obtenir un devis En stock

Other size

Obtenir un devis