DKFZ-938
DKFZ-938 is a kallikrein-related peptidase 6 (KLK6) inhibitor, with an IC50 of 0.09 μM against human KLK6. DKFZ-938 binds to the catalytic serine residue in the active-site pocket of KLK6 and mimics the natural KLK6 substrate to inhibit the enzymatic activity of KLK6. DKFZ-938 can be conjugated to the non-canonical amino acid propargyllysine via copper-catalyzed azide-alkyne cycloaddition click chemistry. DKFZ-938 is used in research related to colorectal cancer and pancreatic cancer.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Formule: C35H41N9O8
- Masse moléculaire:715.76
-
Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
KLK6 0.09 μM (IC50) |
In Vitro
DKFZ-938 (0-3000 nM; 30 min) exhibits potent covalent inhibitory activity against purified KLK6 in a cell-free biochemical assay, with an IC50 of 0.09 μM and a kinact/Ki of 1030 M-1s-1 [1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
Masse moléculaire 715.76
-
Formule C35H41N9O8
-
SMILES
O=C(COC1=CC=C(N2C(C)=C(NC(COC(CC3=C(C)NC4=C3C=C(C#N)C=C4)=O)=O)C(C)=N2)C=C1)NCCOCCOCCOCCN=[N+]=[N-]
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DKFZ-938 Related Classifications
HY-189205 Related Classifications
Powered by Bioz