EF1500
EF1500 is a potent human GABA transporter 1 (hGAT1) inhibitor and a lipophilic THPO analog. EF1500 occupies the binding site by forming a hydrogen bond with active residues of hGAT1 (such as Tyr139) through its exocyclic amino group, thereby blocking GABA reuptake. EF1500 can be used for research on central nervous system diseases.
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- CAS No.: 738562-57-7
- Formule: C21H24N2O2S2
- Masse moléculaire:400.56
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
In Vitro
EF1500 binds effectively to hGAT1, with a binding energy of -9.19 kcal/mol for R-EF1500 to hGAT1 and -8.34 kcal/mol for S-EF1500 to hGAT1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. .
Chemical Information
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CAS No. 738562-57-7
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Masse moléculaire 400.56
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Formule C21H24N2O2S2
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SMILES
O=C1NOC2=C1C(NCCC=C(C=3SC=CC3C)C=4SC=CC4C)CCC2
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EF1500 Related Classifications
HY-189042 Related Classifications
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