738562-57-7
738562-57-7
Chemical Structure
EF1500
- CAS No.: 738562-57-7
- Formula:C21H24N2O2S2
- Molecular Weight:400.56
IUPAC Name: 4-((4,4-bis(3-methylthiophen-2-yl)but-3-en-1-yl)amino)-4,5,6,7-tetrahydrobenzo[d]isoxazol-3(2H)-one
InChIKey: TYXWOLAOXRISSO-UHFFFAOYSA-N
SMILES: O=C1NOC2=C1C(NCCC=C(C=3SC=CC3C)C=4SC=CC4C)CCC2
Biological Activity: EF1500 is a potent human GABA transporter 1 (hGAT1) inhibitor and a lipophilic THPO analog. EF1500 occupies the binding site by forming a hydrogen bond with active residues of hGAT1 (such as Tyr139) through its exocyclic amino group, thereby blocking GABA reuptake. EF1500 can be used for research on central nervous system diseases[1].
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EF1500 | EF1500 is a potent human GABA transporter 1 (hGAT1) inhibitor and a lipophilic THPO analog. EF1500 occupies the binding site by forming a hydrogen bond with active residues of hGAT1 (such as Tyr139) through its exocyclic amino group, thereby blocking GABA reuptake. EF1500 can be used for research on central nervous system diseases. | |||||||||||||||||||||
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