EF1500
EF1500 is a potent human GABA transporter 1 (hGAT1) inhibitor and a lipophilic THPO analog. EF1500 occupies the binding site by forming a hydrogen bond with active residues of hGAT1 (such as Tyr139) through its exocyclic amino group, thereby blocking GABA reuptake. EF1500 can be used for research on central nervous system diseases.
For research use only. We do not sell to patients.
- CAS No.: 738562-57-7
- Formula: C21H24N2O2S2
- Molecular Weight:400.56
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
EF1500 binds effectively to hGAT1, with a binding energy of -9.19 kcal/mol for R-EF1500 to hGAT1 and -8.34 kcal/mol for S-EF1500 to hGAT1[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 738562-57-7
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Molecular Weight 400.56
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Formula C21H24N2O2S2
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SMILES
O=C1NOC2=C1C(NCCC=C(C=3SC=CC3C)C=4SC=CC4C)CCC2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
EF1500 Related Classifications
HY-189042 Related Classifications
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