TRAP1 - TNF receptor associated protein 1 Gene

Also Known as HSP75; HSP 75; HSP90L; TRAP-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10131

About TRAP1

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:3,658,037-3,717,524 (from NCBI)

This gene has 17 transcripts (splice variants), 210 orthologues and 3 paralogues. Ubiquitous expression in kidney (RPKM 31.7), heart (RPKM 25.6) and 25 other tissues.

Summary

This gene encodes a mitochondrial chaperone protein that is member of the heat shock protein 90 (HSP90) family. The encoded protein has ATPase activity and interacts with tumor necrosis factor type I. This protein may function in regulating cellular stress responses. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

TRAP1 Products (2)

mRNA	Protein	Name
NM_001272049.2	NP_001258978.1	heat shock protein 75 kDa, mitochondrial isoform 2
NM_016292.3	NP_057376.2	heat shock protein 75 kDa, mitochondrial isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Références	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17579517	GOA
enables protein kinase binding	IPI IPI: Inferred from physical interaction	17579517	GOA

Biological Process GO Annotation	Evidence	Références	Source
involved in negative regulation of cellular respiration	IMP IMP: Inferred from mutant phenotype	23564345	GOA
involved in translational attenuation	IMP IMP: Inferred from mutant phenotype	24113185	GOA

Cellular Component GO Annotation	Evidence	Références	Source
located in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	23564345	GOA
located in mitochondrial matrix	IDA IDA: Inferred from direct assay	23564345	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	17579517	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRAP1 Protein Structure

HATPase_c_3

HSP90

0
200
400
600
704 a.a.

Protein Preferred Names	Protein Names
heat shock protein 75 kDa, mitochondrial	TNFR-associated protein 1

Recombinant TRAP1 Proteins

Cat. No.	Nom du produit	Accession	Pureté
HY-P71537	TRAP1 Protein, Human (GST)	Q12931 (S60-E308)	≥ 90%, as determined by reducing SDS-PAGE.

TRAP1 Anticorps

Cat. No.	Nom du produit	Application	Reactivity
HY-P82880	Hsp75 Antibody (YA2625)	WB, IHC-P, ICC/IF	Human

Related Diseases

Diseases	Alias
Cakut	Renal Or Urinary Tract Malformation Congenital Anomalies Of Kidney And Urinary Tract Congenital Anomaly Of Kidney And Urinary Tract Congenital Anomalies Of The Kidney And Urinary Tract Kidney And Urinary Tract, Anomalies, Congenital Renal Hypodysplasia, Nonsyndromic, 1
Vacterl Association, X-Linked, With Or Without Hydrocephalus	VACTERLX X-Linked Vacterl Association Vacterl-H, X-Linked Vacterl Association, X-Linked Vacterl Association, X-Linked With Or Without Hydrocephalus Vacterl Association X-Linked With Or Without Hydrocephalus Vacterl Syndrome Vertebral Anal Tracheoesophageal Esophageal Radial Anomalies X-Linked Vacterl-H Vacterl Association Vacterl Association With Hydrocephalus
Retinitis Pigmentosa 71	RP71 Retinitis Pigmentosa, Type 71
Short-Rib Thoracic Dysplasia 10 With Or Without Polydactyly	SRTD10 Short-Rib Thoracic Dysplasia 10 Without Polydactyly Short Rib-Polydactyly Syndrome
Vacterl Association	Vater Association Vater Syndrome
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (20)

Cat. No.	Nom du produit	Effect	Pureté	Rare Diseases
HY-10214	SNX-2112		99.49%	Unkown
HY-10942	VER-82576	Inhibitor	98.76%	Unkown
HY-169369	TRAP-1		99.69%	Unkown
HY-N0237	Atractyloside A		98.11%	Unkown
HY-W004292	1-Undecanol		99.79%	Unkown
HY-115781	DN401	Inhibitor	≥99.0%	Unkown
HY-117395	PU-H54	Inhibitor	99.04%	Unkown
HY-147696	SMTIN-T140		99.54%	Unkown
HY-155063	TRAP1-IN-1	Inhibitor	96.03%	Unkown
HY-W004292S	1-Undecanol-d23		98.2%	Unkown
HY-144830	6BrCaQ	Inhibitor	/	Unkown
HY-144831	6BrCaQ-C10-TPP	Inhibitor	/	Unkown
HY-155064	TRAP1-IN-2	Inhibitor	/	Unkown
HY-181014	Glucocorticoid receptor modulator 5		/	Unkown
HY-182302	SMTIN-P01	Inhibitor	/	Unkown
HY-RS14454	TGFBRAP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14984	TRAP1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W004292S1	1-Undecanol-d4		/	Unkown
HY-RS17512	Trap1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23969	Trap1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TRAP1	VGNC	VGNC:36283
Macaca mulatta	TRAP1	VGNC	VGNC:79019
Mus musculus	TRAP1	MGD	MGI:1915265
Felis catus	TRAP1	VGNC	VGNC:66507
Rattus norvegicus	TRAP1	RGD	RGD:1359733
Canis familiaris	TRAP1	VGNC	VGNC:47776
Others	TRAP1	NCBI