Snap25 - synaptosome associated protein 25 Gene

Also Known as SNAP-25B; SNAP-25a

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25012

Summary

Synaptic vesicle membrane docking and fusion is mediated by SNAREs (soluble N-ethylmaleimide-sensitive factor attachment protein receptors) located on the vesicle membrane (v-SNAREs) and the target membrane (t-SNAREs). The assembled v-SNARE/t-SNARE complex consists of a bundle of four helices, one of which is supplied by v-SNARE and the Other three by t-SNARE. For t-SNAREs on the plasma membrane, the protein syntaxin supplies one helix and the protein encoded by this gene contributes the Other two. Therefore, this gene product is a presynaptic plasma membrane protein. It is essential for regulated exocytosis in neuronal cells. Alternative transcript variants encoding two different protein isoforms have been described for this gene. [provided by RefSeq, Jul 2012]

Snap25 Products (3)

mRNA Protein Name
NM_001270575.1 NP_001257504.1 synaptosomal-associated protein 25 isoform a
NM_001270576.1 NP_001257505.1 synaptosomal-associated protein 25 isoform a
NM_030991.3 NP_112253.1 synaptosomal-associated protein 25 isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables SNARE binding IDA
IDA: Inferred from direct assay
7553862 RGD
enables SNARE binding IPI
IPI: Inferred from physical interaction
7698987 RGD
enables calcium-dependent protein binding IPI
IPI: Inferred from physical interaction
12526776 RGD
enables myosin binding IPI
IPI: Inferred from physical interaction
16030255 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
9759724 RGD
enables protein domain specific binding IPI
IPI: Inferred from physical interaction
11152476 RGD
enables syntaxin-1 binding IDA
IDA: Inferred from direct assay
7553862 RGD
enables syntaxin-1 binding IPI
IPI: Inferred from physical interaction
16030255 RGD
enables transmembrane transporter binding IPI
IPI: Inferred from physical interaction
19077057 RGD
enables voltage-gated potassium channel activity IDA
IDA: Inferred from direct assay
16478442 RGD
Biological Process GO Annotation Evidence Références Source
involved in SNARE complex assembly IMP
IMP: Inferred from mutant phenotype
9671503 RGD
involved in axonogenesis IEP
IEP: Inferred from expression pattern
15478103 RGD
involved in calcium ion-regulated exocytosis of neurotransmitter IDA
IDA: Inferred from direct assay
14980208 RGD
involved in endosomal transport IDA
IDA: Inferred from direct assay
16481393 RGD
involved in long-term memory IMP
IMP: Inferred from mutant phenotype
16870134 RGD
involved in neuron differentiation IEP
IEP: Inferred from expression pattern
24841827 RGD
involved in positive regulation of hormone secretion IMP
IMP: Inferred from mutant phenotype
15147232 RGD
involved in positive regulation of insulin secretion IEP
IEP: Inferred from expression pattern
15042624 RGD
involved in regulation of neuron projection development IMP
IMP: Inferred from mutant phenotype
21986494 RGD
involved in regulation of synapse assembly IEP
IEP: Inferred from expression pattern
15478103 RGD
involved in synaptic vesicle exocytosis EXP
EXP: Inferred from Experiment
8103915 RGD
involved in synaptic vesicle exocytosis IDA
IDA: Inferred from direct assay
8103915 RGD
involved in synaptic vesicle exocytosis IEP
IEP: Inferred from expression pattern
8103915 RGD
Cellular Component GO Annotation Evidence Références Source
part of SNARE complex IDA
IDA: Inferred from direct assay
16030255 RGD
located in actin cytoskeleton IDA
IDA: Inferred from direct assay
10625663 RGD
located in axon IDA
IDA: Inferred from direct assay
10712642 RGD
located in axonal growth cone IDA
IDA: Inferred from direct assay
10712642 RGD
located in endosome IDA
IDA: Inferred from direct assay
16481393 RGD
is active in extrinsic component of presynaptic membrane IDA
IDA: Inferred from direct assay
15983999 RGD
located in filopodium IDA
IDA: Inferred from direct assay
10625663 RGD
is active in glutamatergic synapse EXP
EXP: Inferred from Experiment
8103915 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
8103915 RGD
located in growth cone IDA
IDA: Inferred from direct assay
16598260 RGD
located in lamellipodium IDA
IDA: Inferred from direct assay
10625663 RGD
located in neuron projection IDA
IDA: Inferred from direct assay
16598260 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
10625663 RGD
located in plasma membrane IDA
IDA: Inferred from direct assay
21986494 RGD
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
7698978 RGD
part of synaptobrevin 2-SNAP-25-syntaxin-1a complex IDA
IDA: Inferred from direct assay
7553862 RGD
part of synaptobrevin 2-SNAP-25-syntaxin-1a complex IMP
IMP: Inferred from mutant phenotype
9671503 RGD
part of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex IDA
IDA: Inferred from direct assay
7553862 RGD
part of synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex IDA
IDA: Inferred from direct assay
19132534 RGD
part of voltage-gated potassium channel complex IDA
IDA: Inferred from direct assay
16478442 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

synaptosomal-associated protein 25

  • SNAP-25

  • SUP

  • super protein

  • synaptosomal-associated 25 kDa protein

  • synaptosomal-associated protein, 25 kDa

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-182539 DD04107 Modulator / Unkown
HY-RS13474 SNAP25 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17856 Snap25 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24325 Snap25 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Snap25 NCBI NCBI:6616