PLAUR - plasminogen activator, urokinase receptor Gene
Also Known as CD87; UPAR; URKR; U-PAR
Species: Homo sapiens
About PLAUR
This gene has 16 transcripts (splice variants), 100 orthologues and 2 paralogues. Biased expression in bone marrow (RPKM 100.8), gall bladder (RPKM 18.1) and 5 other tissues.
Summary
This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. [provided by RefSeq, Jul 2008]
PLAUR Products (4)
| mRNA | Protein | Name |
|---|---|---|
| NM_001005376.3 | NP_001005376.1 | urokinase plasminogen activator surface receptor isoform 2 precursor |
| NM_001005377.3 | NP_001005377.1 | urokinase plasminogen activator surface receptor isoform 3 precursor |
| NM_001301037.2 | NP_001287966.1 | urokinase plasminogen activator surface receptor isoform 4 precursor |
| NM_002659.4 | NP_002650.1 | urokinase plasminogen activator surface receptor isoform 1 precursor |
| Molecular Function GO Annotation | Evidence | Références | Source |
|---|---|---|---|
| enables enzyme binding |
IPI
IPI: Inferred from physical interaction
|
14688365 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
11290596 | GOA |
| enables protein domain specific binding |
IPI
IPI: Inferred from physical interaction
|
12665524 | GOA |
| enables signaling receptor binding |
IPI
IPI: Inferred from physical interaction
|
12665524 | GOA |
| Cellular Component GO Annotation | Evidence | Références | Source |
|---|---|---|---|
| located in cell surface |
IDA
IDA: Inferred from direct assay
|
15922359 | GOA |
| located in plasma membrane |
IDA
IDA: Inferred from direct assay
|
12665524 | GOA |
| part of protein complex involved in cell-matrix adhesion |
IPI
IPI: Inferred from physical interaction
|
24465541 | GOA |
| part of serine-type endopeptidase complex |
IPI
IPI: Inferred from physical interaction
|
22285761 | GOA |
PLAUR Protein Structure
UPAR_LY6: u-PAR/Ly-6 domain (25 - 99)
UPAR_LY6: u-PAR/Ly-6 domain (117 - 199)
UPAR_LY6: u-PAR/Ly-6 domain (216 - 294)
- 0
- 100
- 200
- 300
- 335 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
urokinase plasminogen activator surface receptor |
|
Recombinant PLAUR Proteins
| Cat. No. | Nom du produit | Accession | Pureté |
|---|---|---|---|
| HY-P72433 | uPAR Protein, Human (HEK293, His) | Q03405-1 (L23-R303) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P700843 | uPAR Protein, Human (Biotinylated, HEK293, His-Avi) | Q03405-1 (L23-G305) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P700845 | uPAR Protein, Human (Domain 2&3 , HEK293, His) | Q03405-1 (L115-G305) | ≥ 95%, as determined by reducing Bis-Tris PAGE. |
| HY-P700846 | uPAR Protein, Human (Domain 1, HEK293, His) | Q03405-1 (L23-Y114) | ≥ 95%, as determined by reducing SDS-PAGE. |
| HY-P700847 | uPAR Protein, Human (Domain 3, HEK293, His) | Q03405-1 (R214-G305) | ≥ 95%, as determined by reducing SDS-PAGE. |
PLAUR Anticorps
| Cat. No. | Nom du produit | Application | Reactivity |
|---|---|---|---|
| HY-P81512 | uPAR Antibody (YA1257) | IHC-P | Human |
| HY-P81512A | uPAR Antibody | WB, IHC-P | Human |
| HY-P85824 | uPAR Antibody (YA5516) | WB, ICC/IF, ELISA | Human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Ureter, Cancer Of |
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| Paroxysmal Nocturnal Hemoglobinuria |
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| Focal Segmental Glomerulosclerosis |
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| Mal De Meleda |
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| Pemphigus |
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| Diphtheria |
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| Fibrosarcoma |
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| Colorectal Cancer |
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| Hemoglobinuria |
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| Brain Cancer |
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| Transitional Cell Carcinoma |
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| Glioma |
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| Melioidosis |
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| Pemphigus Vulgaris, Familial |
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| Pelvic Inflammatory Disease |
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| Breast Cancer |
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| Glioblastoma |
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| Ovarian Cancer |
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| Prostate Cancer |
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| Perforated Corneal Ulcer |
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| Lung Cancer |
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| Anaplastic Astrocytoma |
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| Bladder Cancer |
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| Gastric Cancer |
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| Benign Giant Cell Tumor |
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| Pancreatic Cancer |
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| Nephrotic Syndrome |
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| Developmental And Epileptic Encephalopathy 38 |
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| Malaria |
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| Acute Promyelocytic Leukemia |
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| Melanoma |
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| Hepatocellular Carcinoma |
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| High Grade Glioma |
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| Asthma |
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| Lung Squamous Cell Carcinoma |
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| Rhabdomyosarcoma |
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| Heart Disease |
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| Medulloblastoma |
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Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Bos taurus | PLAUR | VGNC | VGNC:32976 |
| Felis catus | PLAUR | VGNC | VGNC:68893 |
| Mus musculus | PLAUR | MGD | MGI:97612 |
| Canis familiaris | PLAUR | VGNC | VGNC:56920 |
| Rattus norvegicus | PLAUR | RGD | RGD:620597 |
| Macaca mulatta | PLAUR | VGNC | VGNC:76163 |
| Others | PLAUR | NCBI |