BGLAP - bone gamma-carboxyglutamate protein Gene
Also Known as OC; BGP; OCN
Species: Homo sapiens
About BGLAP
This gene has 2 transcripts (splice variants) and 115 orthologues. Ubiquitous expression in endometrium (RPKM 1.6), prostate (RPKM 1.4) and 25 other tissues.
Summary
This gene encodes a highly abundant bone protein secreted by osteoblasts that regulates bone remodeling and energy metabolism. The encoded protein contains a Gla (gamma carboxyglutamate) domain, which functions in binding to calcium and hydroxyapatite, the mineral component of bone. Serum osteocalcin levels may be negatively correlated with metabolic syndrome. Read-through transcription exists between this gene and the neighboring upstream gene, PMF1 (polyamine-modulated factor 1), but the encoded protein only shows sequence identity with the upstream gene product. [provided by RefSeq, Jun 2015]
BGLAP Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_199173.6 | NP_954642.1 | osteocalcin preproprotein |
| Molecular Function GO Annotation | Evidence | Références | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
32296183 | GOA |
| Biological Process GO Annotation | Evidence | Références | Source |
|---|---|---|---|
| involved in osteoblast differentiation |
IEP
IEP: Inferred from expression pattern
|
17023519 | GOA |
| involved in response to vitamin D |
IEP
IEP: Inferred from expression pattern
|
17023519 | GOA |
| Cellular Component GO Annotation | Evidence | Références | Source |
|---|---|---|---|
| located in cytoplasm |
IDA
IDA: Inferred from direct assay
|
11856645 | GOA |
BGLAP Protein Structure
Gla: Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain (57 - 98)
- 0
- 100 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
osteocalcin |
|
BGLAP Anticorps
| Cat. No. | Nom du produit | Application | Reactivity |
|---|---|---|---|
| HY-P81217 | Osteocalcin Antibody | WB, ELISA, IHC-P, IHC-F, ICC/IF | Human, Mouse |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Osteitis Fibrosa |
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| Renal Osteodystrophy |
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| Osteonecrosis |
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| Nontoxic Goiter |
|
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| Camurati-Engelmann Disease |
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| Osteoporosis |
|
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| Secondary Hyperparathyroidism |
|
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| Fibrous Dysplasia |
|
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| Fibrosarcomatous Osteosarcoma |
|
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| Vitamin K Deficiency Bleeding |
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| Rickets |
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| Osteomalacia |
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| Bone Disease |
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| Hyperparathyroidism |
|
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| Chondroblastic Osteosarcoma |
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| Hyperthyroidism |
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| Primary Hyperparathyroidism |
|
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| Osteoporosis, Juvenile |
|
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| Hypoparathyroidism |
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| Hypophosphatemia |
|
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| Pseudohypoparathyroidism |
|
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| Osteopetrosis, Autosomal Dominant 2 |
|
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| Glucocorticoid-Induced Osteoporosis |
|
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| Bone Resorption Disease |
|
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| Paget'S Disease Of Bone |
|
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| Hemarthrosis |
|
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| Osteofibrous Dysplasia |
|
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| Chronic Kidney Disease |
|
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| Thyrotoxic Exophthalmos |
|
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| Bone Remodeling Disease |
|
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| Acromegaly |
|
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| Osteogenesis Imperfecta, Type I |
|
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| Rhinitis |
|
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| Goiter |
|
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| Brittle Bone Disorder |
|
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| Hyperphosphatemia |
|
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| Osseous Heteroplasia, Progressive |
|
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| Periodontitis |
|
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| Cleidocranial Dysplasia |
|
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| Ischemic Bone Disease |
|
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| Pseudohypoparathyroidism, Type Ib |
|
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| Hemiplegia |
|
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| Osteopetrosis |
|
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| Endocrine Exophthalmos |
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| Achondroplasia |
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| Hypogonadism |
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| Osteoarthritis |
|
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| Amenorrhea |
|
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| Spondyloarthropathy 1 |
|
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| Parathyroid Gland Disease |
|
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| Type 1 Diabetes Mellitus |
|
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| Hyperprolactinemia |
|
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| Conn'S Syndrome |
|
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| Benign Giant Cell Tumor |
|
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| Saethre-Chotzen Syndrome |
|
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| Aggressive Periodontitis |
|
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| Nutritional Deficiency Disease |
|
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| Tooth Resorption |
|
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| Dental Pulp Disease |
|
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| Anorexia Nervosa |
|
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| Dental Pulp Necrosis |
|
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| Osteogenesis Imperfecta, Type Xxi |
|
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| Asthma |
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| Hypocalcemia, Autosomal Dominant 1 |
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| Osteogenic Sarcoma |
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| Hypopituitarism |
|
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| Extraosseous Osteosarcoma |
|
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| Mammary Paget'S Disease |
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| Hypogonadism, Male |
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| Juvenile Rheumatoid Arthritis |
|
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| Ossification Of The Posterior Longitudinal Ligament Of Spine |
|
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| Insulin-Like Growth Factor I |
|
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| Beta-Thalassemia |
|
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| Mineral Metabolism Disease |
|
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| Abetalipoproteinemia |
|
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| Van Buchem Disease |
|
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| Periapical Periodontitis |
|
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| Prolactinoma |
|
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| Ankylosis |
|
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| Myositis Ossificans |
|
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| Kidney Disease |
|
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| Phosphorus Metabolism Disease |
|
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| Sclerosteosis |
|
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| Hypothyroidism |
|
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| Scoliosis |
|
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| Rheumatoid Arthritis |
|
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| Multicentric Carpotarsal Osteolysis Syndrome |
|
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| Bone Development Disease |
|
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| Sclerosteosis 1 |
|
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| Hypophosphatasia |
|
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| Dental Fluorosis |
|
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| Craniometaphyseal Dysplasia, Autosomal Dominant |
|
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| Gaucher'S Disease |
|
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| Prostate Cancer |
|
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| Pycnodysostosis |
|
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| Chronic Recurrent Multifocal Osteomyelitis |
|
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| Osteoblastoma |
|
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| Cerebral Palsy |
|
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| Exostosis |
|
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| Muscular Atrophy |
|
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| Hypophosphatemic Rickets, X-Linked Dominant |
|
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| Aortic Valve Disease 1 |
|
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| Diffuse Idiopathic Skeletal Hyperostosis |
|
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| Inflammatory Bowel Disease |
|
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| Breast Adenocarcinoma |
|
|
| Teeth Hard Tissue Disease |
|
|
| Primary Biliary Cholangitis |
|
|
| Type 2 Diabetes Mellitus |
|
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| Bone Osteosarcoma |
|
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| Diabetes Mellitus |
|
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| Osteochondrodysplasia |
|
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| Essential Thrombocythemia |
|
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| Bone Structure Disease |
|
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| Myeloma, Multiple |
|
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| Meckel Syndrome, Type 7 |
|
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| Aortic Valve Disease 2 |
|
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| Crouzon Syndrome |
|
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| Osteogenesis Imperfecta, Type Iii |
|
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| Cystic Fibrosis |
|
|
| Beta-Thalassemia Major |
|
|
| Premature Menopause |
|
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| Craniosynostosis |
|
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| Connective Tissue Disease |
|
|
| Breast Cancer |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Rattus norvegicus | BGLAP | RGD | RGD:2206 |
| Bos taurus | BGLAP | VGNC | VGNC:26480 |
| Canis familiaris | BGLAP | VGNC | VGNC:38442 |
| Others | BGLAP | NCBI |