MBXC-4522
MBXC-4522 is an RVFV-EndoN inhibitor with an IC50 of 2.8 μM. MBXC-4522 exhibits antiviral activity. MBXC-4522 binds to and stabilizes the RVFV endonuclease through a metal-independent mechanism, inhibiting its activity and thereby blocking the viral "cap-snatching" mechanism. MBXC-4522 can be used for research on Rift Valley fever virus infection.
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- CAS No.: 1340680-75-2
- Formule: C23H29N5O2S
- Masse moléculaire:439.57
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Activité biologique
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Activité biologique
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | CC50 |
30.1 μM
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Cytotoxicity against human HEK293 cells assessed as reduction in cell viability by CellTiter Glo 2.0 assay.
Cytotoxicity against human HEK293 cells assessed as reduction in cell viability by CellTiter Glo 2.0 assay.
|
40787859 |
| HepG2 | CC50 |
73.8 μM
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Cytotoxicity against human HepG2 cells assessed as reduction in cell viability by CellTiter Glo 2.0 assay.
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability by CellTiter Glo 2.0 assay.
|
40787859 |
| Vero | CC50 |
45.0 μM
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Cytotoxicity against african green monkey Vero cells assessed as reduction in cell viability by CellTiter Glo 2.0 assay.
Cytotoxicity against african green monkey Vero cells assessed as reduction in cell viability by CellTiter Glo 2.0 assay.
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40787859 |
| BV-2 | CC50 |
43.0 μM
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Cytotoxicity against mouse BV2 cells assessed as reduction in cell viability by CellTiter Glo 2.0 assay.
Cytotoxicity against mouse BV2 cells assessed as reduction in cell viability by CellTiter Glo 2.0 assay.
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40787859 |
In Vitro
MBXC-4522 (5-50 μM; 16 h) significantly inhibits RVFV-MP12GFP attenuated virus infection in BV2 cells[1].
MBXC-4522 inhibits purified RVFV-EndoN endonuclease activity in a dose-dependent manner, with an IC50 of 2.8 μM[1].
MBXC-4522 (5-50 μM; 18 h) inhibits RVFV (ZH501), SFTSV, and HRTV viral antigen expression, plaque formation, and reduces viral RNA levels in Vero E6 cells[1].
MBXC-4522 (0.1-100 μM; 72 h) exhibits dose-dependent cytotoxicity with low cytotoxicity in HEK293 (CC50 = 30.1 µM), HepG2 (CC50 = 73.8 µM), Vero (CC50 = 45.0 µM), and BV2 (CC50 = 43.0 µM) cell lines[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HEK293, HepG2, Vero6, BV2
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Concentration:0.01, 0.03, 0.1, 0.3, 1, 3, 10, 30, 100 μM
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Incubation Time:72 h
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Result:Exhibited CC50 values of 30.1 μM in HEK293 cells, 73.8 μM in HepG2 cells, 45.0 μM in Vero6 cells, and 43.0 μM in BV2 cells.
Chemical Information
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CAS No. 1340680-75-2
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Masse moléculaire 439.57
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Formule C23H29N5O2S
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SMILES
O=S(C1=C(C)C=CC=C1)(N2CC3(NC4=CC=CN=C4N=C3NC5CCCC5)CCC2)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
MBXC-4522 Related Classifications
HY-187464 Related Classifications
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