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Cat. No.: HY-P10055

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PSMA targeting peptide

Name: PSMA targeting peptide
Brand: MedChemExpress
SKU: HY-P10055
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(Synonyms: PSMA-1)

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

PSMA targeting peptide (PSMA-1) is a PSMA-binding peptide that selectively binds to the PSMA receptor on prostate cancer cells and acts as a peptide-based siRNA delivery system by complexing and releasing siRNA. PSMA targeting peptide can be used in research on prostate cancer.

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CAS No.: 2042750-71-8
Formule: C₇₀H₁₂₂N₂₄O₁₉
Masse moléculaire:1603.87

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Please store the product under the recommended conditions in the Certificate of Analysis.

PSMA targeting peptide Chemical Structure

CAS No.: 2042750-71-8

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Fluorescent Dye

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (1)
Protocole (1)
Pureté et documentation
Références
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Activité biologique

Description

IC₅₀ & Target

IC50: PSMA^[1]

In Vitro

PSMA-1-R6 forms large, anionic, polydisperse complexes with siRNA, with a zeta potential of -2.16 mV, effective diameters of 1450 nm (aggregates) and 878 nm (individual particles), and a tendency to aggregate^[1].
PSMA-1-R6 (5 min; 1 week), when complexed with siRNA, formed large, polydisperse aggregated particles with an average size 200-300 nm larger than that of the siRNA:Trans-IT X2 control complexes^[1].
PSMA-1-R6 peptide (625 pmol; 48 h) failed to mediate functional siRNA delivery and GRP78 knockdown at both mRNA and protein levels in both LNCaP and PC3 cell lines^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

CAS No. 2042750-71-8
Masse moléculaire 1603.87
Formule C₇₀H₁₂₂N₂₄O₁₉
Synonyms

PSMA-1
Sequence

Gly-Arg-Phe-Leu-Thr-Gly-Gly-Thr-Gly-Arg-Leu-Leu-Arg-Ile-Ser
Sequence Shortening

GRFLTGGTGRLLRIS
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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J Control Release

Targeting polyamine metabolism induces oxidative/carbonyl stress to reinvigorate antitumor immunity in prostate cancer. [Abstract]

2025 Sep 30;388(Pt 1):114283. PMID: 41038348

Protocole

All Molecular Biology

RNA interference technology
RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing gene transcription or activating RNA degradation. This mechanism was discovered in plants in 1998 by Andrew Fire and Craig Mello. Today, this phenomenon can be observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals.

Pureté et documentation

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Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Cultrara CN, et al. Size Matters: Arginine-Derived Peptides Targeting the PSMA Receptor Can Efficiently Complex but Not Transfect siRNA. Molecular therapy. Nucleic acids. 2019 Dec 06;18:863-870. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Keywords

PSMA targeting peptide

1 Cited Publications

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (1)
Protocole
Pureté et documentation
Références

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PSMA targeting peptide

Publications Citing Use of MedChemExpress (MCE) PSMA targeting peptide