Microbial transformation of trichostatin A to 2,3-dihydrotrichostatin A

  • J Nat Prod. 2011 May 27;74(5):1272-4. doi: 10.1021/np1006718.
Je Won Park  1 ,  Sung Ryeol Park ,  Ah Reum Han ,  Yeon-Hee Ban ,  Young Ji Yoo ,  Eun Ji Kim ,  Eunji Kim ,  Yeo Joon Yoon
Affiliations
  • 1. Department of Pharmaceutical Engineering, Institute of Biomolecule Reconstruction, Sun Moon University, Chungnam 336-708, Republic of Korea.
PMID: 21504214 DOI: 10.1021/np1006718
Abstract

A new reduced hydroxamate, 2,3-dihydrotrichostatin A, was created from trichostatin A by employing a Recombinant strain of Streptomyces venezuelae as a microbial catalyst. Compared with trichostatin A, 2,3-dihydrotrichostatin A showed similar Antifungal activity against Saccharomyces cerevisiae, but, interestingly, approximately twice the cytostatic activity against human small-cell Lung Cancer cells. The production of 2,3-dihydrotrichostatin A via microbial biotransformation demonstrates that the regiospecific and substrate-flexible hydrogenation by S. venezuelae provides a new approach for creating natural product analogues with improved bioactive properties.