Synthesis of acyclo-C-nucleosides in the imidazo[1,2-a]pyridine and pyrimidine series as antiviral agents

  • J Med Chem. 1996 Jul 5;39(14):2856-9. doi: 10.1021/jm9507901.
A Gueiffier  1 ,  M Lhassani ,  A Elhakmaoui ,  R Snoeck ,  G Andrei ,  O Chavignon ,  J C Teulade ,  A Kerbal ,  E M Essassi ,  J C Debouzy ,  M Witvrouw ,  Y Blache ,  J Balzarini ,  E De Clercq ,  J P Chapat
Affiliations
  • 1. Laboratoire de Chimie Organique Pharmaceutique, URA-CNRS 1111, Montpellier, France.
PMID: 8709116 DOI: 10.1021/jm9507901
Abstract

The synthesis and the Antiviral activities of C-3 acyclic nucleoside analogues of imidazo[1,2-a]pyridine and pyrimidine are reported. From these compounds, 20, 21, 22, 23, 28, and 34 showed a specific activity against cytomegalovirus and/or varicella-zoster virus.