Lysophosphatidic acid: G-protein signalling and cellular responses

  • Curr Opin Cell Biol. 1997 Apr;9(2):168-73. doi: 10.1016/s0955-0674(97)80059-2.
W H Moolenaar  1 ,  O Kranenburg ,  F R Postma ,  G C Zondag
Affiliations
  • 1. Division of Cellular Biochemistry, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 X Amsterdam, The Netherlands. [email protected]
PMID: 9069262 DOI: 10.1016/s0955-0674(97)80059-2
Abstract

Lysophosphatidic acid (LPA) is a serum-borne phospholipid that activates a specific G protein coupled receptor to evoke multiple cellular responses. Recent work has identified two cDNAs encoding putative LPA receptors, various LPA-like agonists that act on distinct receptors, and new pathways that link the receptor(s) to such diverse events as Ras signalling, cytoskeletal remodelling and membrane depolarization.