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Cat. No.: HY-123313

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S-8660

S-8660 is an orally active and selective inhibitor of dihydroorotate dehydrogenase (DHODH). S-8660 is an analog of Brequinar (HY-108325) and exhibits immunosuppressive activity. When combined with Cyclosporin A (HY-B0579), it enhances the effect of prolonging cardiac allograft survival. S-8660 can be used for research on cardiac transplant rejection.

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CAS No.: 96201-52-4
Formule: C₂₃H₁₆ClNO₂
Masse moléculaire:373.83

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

S-8660 Chemical Structure

CAS No.: 96201-52-4

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

In Vitro

Nucleotide MetabolismOthers

Nucleotide Metabolism

S-8660 selectively inhibits mitochondrial dihydroorotate dehydrogenase, disrupting de novo pyrimidine synthesis in a cell-free biochemical system^[1].

Others

S-8660 suppresses human mixed-lymphocyte responses in vitro^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

S-8660 (5-20 mg/kg; p.o.; once daily; starting 2 days pre-transplant for up to 30 days post-transplant) prolongs cardiac allograft survival in rats in a dose-dependent fashion, with a tapered dose regimen achieving a median survival time of 32 days^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

ACI (RT1a) donors; Lewis (RT1¹) recipients^[1]
Dosage:

5 mg/kg; 20 mg/kg
Administration:

p.o.; once daily; starting 2 days pre-transplant for up to 30 days post-transplant
Result:

Extended cardiac allograft survival in a dose-dependent manner.
Achieved a median graft survival time of 32 days with the tapered dose regimen, compared to control median survival of 7 days.

Chemical Information

CAS No. 96201-52-4
Masse moléculaire 373.83
Formule C₂₃H₁₆ClNO₂
SMILES

O=C(O)C1=C(C(C2=CC=C(C=C2)C3=CC=CC=C3)=NC4=CC=CC(Cl)=C14)C
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Cramer DV, et al. Inhibition of the pyrimidine biosynthetic pathway with S-8660, an analogue of brequinar sodium, prolongs cardiac allograft survival in rats. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation. 1993;12(1 Pt 1):140-6.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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