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Cat. No.: HY-182252

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SAR296968

SAR296968 is a Na⁺/Ca²⁺ exchanger (NCX) subtype inhibitor with an IC₅₀ value of 74 nM against hNCX1. SAR296968 inhibits both forward and reverse modes of NCX current. SAR296968 enhances cardiac contractility and stroke volume. SAR296968 exerts antiarrhythmic effects. SAR296968 is applicable to research related to heart failure.

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CAS No.: 1426899-28-6
Formule: C₂₂H₂₂N₂O₄S
Masse moléculaire:410.49

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

SAR296968 Chemical Structure

CAS No.: 1426899-28-6

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
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Activité biologique

Description

In Vitro

SAR296968 potently inhibits hNCX1 in CHO cell lines, with an IC₅₀ value of 74 nM^[1].
SAR296968 potently inhibits both forward and reverse modes of endogenous NCX currents in guinea pig cardiomyocytes, with corresponding IC₅₀ values of 34.9 nM and 38.9 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SAR296968 (1.5 mg/kg; i.v.; over 20 minutes) (administered as SAR340835, its prodrug) increases left ventricular contractility by 49% and reduces electrically induced atrial arrhythmias by 74% in anesthetized pigs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

unspecified strain (pentobarbital-anesthetized)^[1]
Dosage:

1.5 mg/kg
Administration:

i.v.; over 20 minutes
Result:

Increased left ventricular contractility by 49% (dP/dtmax rose from 1423 ± 144 mm Hg/s at baseline to 2115 ± 189 mm Hg/s post-infusion).
Reduced the incidence of atrial arrhythmias by 74% (6.56 ± 1.99 events post-treatment vs.
25.50 ± 1.75 events at baseline, n=8, P<0.001).
Showed no changes in left or right atrial effective refractory period regardless of basic cycle length.

Chemical Information

CAS No. 1426899-28-6
Masse moléculaire 410.49
Formule C₂₂H₂₂N₂O₄S
SMILES

CC(C=CC=C1)=C1[C@H]2OC3=CC=C(C=C3CC2)OC4=NC=C(C(NCCO)=O)S4
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Pelat M, et al. SAR340835, a Novel Selective Na⁺/Ca²⁺ Exchanger Inhibitor, Improves Cardiac Function and Restores Sympathovagal Balance in Heart Failure. J Pharmacol Exp Ther. 2021;377(2):293-304. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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