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Cat. No.: HY-181352

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SB-140

SB-140 is a selective, covalent PLpro inhibitor with an IC₅₀ of ≤2.5 nM against SARS-CoV-2 PLpro. SB-140 has antiviral activity against SARS-CoV-2, MERS-CoV and SARS-CoV-1.

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Formule: C₂₈H₃₅F₃N₄O₃
Masse moléculaire:532.60

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

SB-140 Chemical Structure

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Quantité

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- In Vitro
- In Vivo
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

SB-140 is a selective, covalent PLpro inhibitor with an IC₅₀ of ≤2.5 nM against SARS-CoV-2 PLpro. SB-140 has antiviral activity against SARS-CoV-2, MERS-CoV and SARS-CoV-1^[1].

In Vitro

SB-140 (15 min) potently inhibits purified SARS-CoV-2 PLpro with an IC₅₀ ≤ 2.5 nM^[1].
SB-140 (1 μM) exhibits high selectivity, with no inhibitory activity detected against 47 human DUBs and 9 cysteine proteases at a concentration of 1 μM^[1].
SB-140 (0-10 μM; 1 h) potently inhibits SARS-CoV-2 replication in A549-ACE2 cells, with an EC₅₀ of 0.3 nM and an EC₉₀ of 3 nM^[1].
SB-140 (0.01-100 μM) exhibits attenuated inhibitory activity against MERS-CoV replication in A549-ACE2 cells, with an EC₅₀ of 1.17 μM^[1].
SB-140 (0-1 μM) inhibits SARS-CoV-1 in A549-ACE2 cells, with an EC₅₀ of 14.1 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

SB-140 (10 mg/kg; i.p.; twice daily; 5 days) reduces lung viral load by 15-fold in K18-hACE2 mice infected with SARS-CoV-2 variant β^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

Masse moléculaire 532.60
Formule C₂₈H₃₅F₃N₄O₃
SMILES

CCOC1=CC2=C(C=CC=C2[C@@H](C)N3CCC([C@@H](CN)C(NCC(NCC#CC(F)(F)F)=O)=O)CC3)C=C1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Sharafi M, et al. Structure-Guided Design of Potent and Selective Covalent Inhibitors Targeting the SARS-CoV-2 Papain-like Protease. J Med Chem. 2026;69(3):2197-2214. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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