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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
128 Results for "
Mouse IFN-
" in MedChemExpress (MCE) Product Catalog:
Products (128)
128 Results for "Mouse IFN-" in MCE Product Catalog:
54
33
33 Cited Publications
Cat. No.: HY-P7063
Pureté: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IL6; Hybridoma Growth Factor; Prev. IFNB2; IFN-Beta-2; IL-6; BSF-2; Interleukin-6; CDF; BSF2; Interleukin 6 (Interferon, Beta 2); HGF; B-Cell Differentiation Factor; HSF; Truncated Interleukin 6; B-Cell Stimulatory Factor 2; Interferon, Beta 2; CTL Differentiation Factor; Interleukin BSF-2; Interleukin 6; Interferon Beta-2
Species:
Mouse
Source:
E. coli
23
Domaines de recherche:
Itacitinib (INCB039110) is an orally active selective inhibitor of JAK1 with an IC50 value of 2 nM for human JAK1. Itacitinib inhibits IFN-γ-mediated phosphorylation of STAT1 and downstream pro-inflammatory signaling pathways. Itacitinib reduces the frequency and number of splenic neutrophils in mouse models, downregulates the levels of pro-inflammatory cytokines and chemokines, and inhibits pro-inflammatory gene expression pathways. Itacitinib improves survival rate and clinical scores in mouse models of hemophagocytic lymphohistiocytosis (HLH), and also suppresses metastasis in NSCLC models with high Rab1A expression. Itacitinib can be used for research on hemophagocytic lymphohistiocytosis and non-small cell lung cancer .
23
Domaines de recherche:
Itacitinib adipate (INCB039110 adipate) is an orally active JAK1-selective inhibitor. Itacitinib adipate inhibits IFN-γ-mediated phosphorylation of STAT1 and downstream pro-inflammatory signaling pathways. Itacitinib adipate reduces the frequency and number of splenic neutrophils in mouse models, downregulates the levels of pro-inflammatory cytokines and chemokines, and inhibits pro-inflammatory gene expression pathways. Itacitinib adipate improves survival rate and clinical scores in mouse models of hemophagocytic lymphohistiocytosis (HLH), and also suppresses metastasis in NSCLC models with high Rab1A expression. Itacitinib adipate can be used for research on hemophagocytic lymphohistiocytosis and non-small cell lung cancer .
12
5
5 Cited Publications
Cat. No.: HY-P73181
Pureté: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: IL18; Interleukin 18 (Interferon-Gamma-Inducing Factor); Interleukin 18; IFN-Gamma-Inducing Factor; IL-18; Interleukin-1 Gamma; IL1F4; Iboctadekin; IGIF; IL-1 Gamma; Interleukin-18; Interferon-Gamma-Inducing Factor; IL-1g; Interferon Gamma-Inducing Factor
Species:
Mouse
Source:
E. coli
4
4 Cited Publications
Cat. No.: HY-P700184AF
Pureté: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IFNG; IMD69; Interferon Gamma; IFG; IFN-Gamma; IFI; Immune Interferon
Species:
Mouse
Source:
E. coli
2
2 Cited Publications
Cat. No.: HY-P990173
Target:
Domaines de recherche:
2
2 Cited Publications
Cat. No.: HY-P99136
Target:
Domaines de recherche:
2
2
2
2 Cited Publications
Cat. No.: HY-P7544
Pureté: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IFNA2; IFN-Alpha-2; Interferon Alpha 2; IFNA2B; IFN-AlphaA; LeIF A; IFNA; Interferon Alpha 2a; Alpha-2a Interferon; Interferon Alpha-A; Interferon Alpha 2b; Interferon 1AB4; Interferon Alpha A; IFNA2C; Interferon Alpha-2; IFNA2A
Species:
Mouse
Source:
E. coli
2
2 Cited Publications
Cat. No.: HY-P74851
Pureté: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IFNL3; Interleukin-28C; Prev. IL28B; IL-28C; IL-28B; Interferon, Lambda 4; IL28C; Interleukin 28B; Interleukin 28B (Interferon, Lambda 3); Interferon 1IA1; Interferon Lambda-3; IFN-Lambda-4; Cytokine Zcyto22; ZCYTO22; Interleukin-28B; Interferon Lambda 3
Species:
Mouse
Source:
HEK293
2
2 Cited Publications
Cat. No.: HY-P74852
Pureté: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IFNGR2; CDNA FLJ78008, Highly Similar To Human Clone PSK1 Interferon Gamma Receptor Accessory Factor-1 (AF-1) MRNA; Prev. IFNGT1; Interferon Gamma Receptor 2 (Interferon Gamma Transducer 1); AF-1; Interferon Gamma Receptor Accessory Factor-1; Interferon G
Species:
Mouse
Source:
HEK293
1
1 Cited Publications
BCI-137 is a Argonaute 2 (AGO2) inhibitor. By inhibiting AGO2 function, reducing PTPN6/SHP-1 protein levels and enhancing STAT1 phosphorylation, BCI-137 restores the sensitivity of tumor cells to IFN-γ. BCI-137 effectively enhances the recruitment, activation and cytotoxicity of CD8 + T cells. BCI-137 exerts a synergistic effect with anti-PD-1 antibodies and significantly reduces tumor volume in preclinical mouse models. BCI-137 exhibits favorable safety profiles and does not cause significant weight loss or death in mice. BCI-137 can be used in research related to bladder cancer, colorectal cancer, melanoma and other related fields .
1
1 Cited Publications
Cat. No.: HY-P990297
Domaines de recherche:
1
1 Cited Publications
Cat. No.: HY-160406
CAS No.: 2332803-84-4
Target:
Domaines de recherche:
SNX281 is a selective STING agonist, with IC50 values of 4.1, 4.5, 10.7, and 3.7 μM against human, mouse, rat, and monkey STING, respectively. SNX281 undergoes homodimerization at the STING binding site, triggering a conformational shift of STING from an inactive open state to an active closed state, thereby driving downstream STING-dependent signaling pathways. SNX281 induces type I interferons, IFN-β, TNF-α, IL-6, cytokine release, T cell responses, and long-lasting immune memory. SNX281 exhibits anti-tumor activity and is applicable to research related to colorectal cancer, melanoma, advanced solid tumors, lymphoma, and ovarian cancer .
1
1 Cited Publications
Cat. No.: HY-P99124
Target:
Domaines de recherche:
1
1
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
