Stilbazium iodide
Stilbazium iodide is an orally effective pyridinium quaternary ammonium repellent. Stilbazium (iodide) exhibits broad-spectrum activity against a variety of human and animal intestinal parasites. Stilbazium iodide eliminates both mature and immature worms, reduces egg counts, reddens feces, and causes mild gastrointestinal irritation. Stilbazium iodide can be used in research related to intestinal parasitic infections including pinworm, whipworm, and strongyloidiasis.
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- CAS No.: 3784-99-4
- Formule: C31H36IN3
- Masse moléculaire:577.54
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
Description
In Vivo
Stilbazium iodide (administered orally via ad libitum feeding for 18 days) exhibits low EC50 and EC90 values against S. obvelata and A. tetraptera, but high values of the above indices against N. dubius, indicating that it exerts potent activity against pinworms and moderate activity against trichostrongylids when administered to infected mice[1].
Stilbazium iodide (200 mg/kg/day; p.o.; once daily; for 3 consecutive days) exhibits complete efficacy against mature S. obvelata infection in infected mice, but shows no efficacy against mature N. dubius or H. nana infection[1].
Stilbazium iodide (2.5-15.0 mg base/kg; p.o.; single dose) completely eliminates Syphacia obvelata in mice at doses of 10.0 mg base/kg and above, and achieves an elimination rate of over 93% even at a dose as low as 2.5 mg base/kg[2].
Stilbazium iodide administered via feed at 25-150 mg/kg food; ad libitum feeding; for 48 h) achieves a clearance rate of 99.2% to 100% against Syphacia obvelata in naturally infected mice, with complete elimination of the parasites in all mice receiving doses of 100 and 150 mg/kg food[3].
Stilbazium iodide (1.5-3.0 g; administered over 3 days; twice daily or three times daily; p.o.) shows significantly variable efficacy against intestinal helminths: moderate efficacy against whipworms (7/24 cures, 76%-97% egg reduction), promising efficacy against strongyloides (apparent clearance in 5/5 cases), poor efficacy against hookworms (2/12 cures, 20%-58% egg reduction), and weak efficacy against Hymenolepis nana and roundworms[5].
Stilbazium iodide (500 mg/kg) shows no acute toxicity in healthy dogs and cats, and has negligible emetic activity[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Swiss-Webster male mice (16 to 20 g body weight) were inoculated via oral gavage on day 0 with 30-50 Nematospiroides dubius larvae and 200 Hymenolepis nana eggs per mouse, while naturally harboring Syphacia obvelata and Aspiculuris tetraptera infections[1]
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Dosage:1000 ppm
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Administration:p.o.; ad libitum; 18 days
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Result:Achieved 82% reduction in N. dubius worm burden (with recovered worms significantly smaller than controls).
Achieved 100% reduction in S. obvelata worm burden.
Achieved 100% reduction in A. tetraptera worm burden.
Showed no activity against H. nana.
Resulted in mouse survival of 22/32 across 4 experiments.
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Animal Model:Swiss-Webster male mice (16 to 20 g body weight) harbored 20-day mature infections of Nematospiroides dubius (30-50 larvae per mouse) and Hymenolepis nana (200 eggs per mouse), as well as naturally acquired mature Syphacia obvelata infections[1]
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Dosage:200 mg/kg/day
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Administration:p.o.; once daily; 3 days
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Result:Achieved 0% reduction in N. dubius worm burden.
Achieved 0% reduction in H. nana worm burden.
Resulted in mouse survival of 17/24 across 3 experiments.
Achieved 100% reduction in S. obvelata worm burden.
Resulted in mouse survival of 22/24 across 3 experiments.
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Animal Model:Mice (28-32 g) used in the experiments had natural infections of Syphacia obvelata[2]
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Dosage:2.5, 5.0, 7.5, 10.0, 12.5 and 15.0 mg base/kg
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Administration:p.o.; single dose
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Result:Achieved 100% elimination of all (young and mature) Syphacia obvelata worms, with 24/24, 23/23, and 24/24 mice completely cleared of infection at 15.0, 12.5, and 10.0 mg base/kg, respectively.
Eliminated 98.4% of all worms, with 14/23 mice cleared at 7.5 mg base/kg.
Eliminated 98.6% of all worms, with 15/22 mice cleared at 5.0 mg base/kg.
Eliminated 93.1% of all worms, with 9/24 mice cleared at 2.5 mg base/kg; mice expelled 266-391 worms each at this dose.
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Animal Model:Ha/ICR Swiss male mice (25-30 g) naturally infected with Syphacia obvelata
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Dosage:25, 50, 100, 150 mg/kg food
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Administration:p.o.; ad libitum; 48 hours
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Result:Achieved average 99.2% worm elimination, with 21/24 mice cleared of infection, and average drug base intake of 4.6 mg/kg body weight at 25 mg/kg food.
Achieved average 99.9% worm elimination, with 23/24 mice cleared of infection, and average drug base intake of 9.0 mg/kg body weight at 50 mg/kg food.
Achieved average 100% worm elimination, with 24/24 mice cleared of infection, and average drug base intake of 19.2 mg/kg body weight at 100 mg/kg food.
Achieved average 100% worm elimination, with 24/24 mice cleared of infection, and average drug base intake of 30.4 mg/kg body weight at 150 mg/kg food.
Eliminated 56% of worms in the first 24 hours at 25 mg/kg food.
Eliminated 47% of worms in the first 24 hours at 50 mg/kg food.
Eliminated 88% of worms in the first 24 hours at 100 mg/kg food.
Eliminated 94% of worms in the first 24 hours at 150 mg/kg food.
Left only 7 of 8,514 total harbored pinworms alive post-treatment across all groups.
Chemical Information
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CAS No. 3784-99-4
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Masse moléculaire 577.54
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Formule C31H36IN3
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SMILES
CC[N+]1=C(/C=C/C2=CC=C(N3CCCC3)C=C2)C=CC=C1/C=C/C4=CC=C(N5CCCC5)C=C4.[I-]
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Brody G, et al. Comparative activity of 29 known anthelmintics under standardized drug-diet and gavage medication regimens against four helminth species in mice. J Parasitol. 1971 Oct;57(5):1068-77. [Content Brief]
[2]. BURROWS RB, et al. Stilbazium iodide as an anthelmintic. I. Against Syphacia obvelata in mice. J Parasitol. 1962 Oct;48:767-8. [Content Brief]
[3]. HUNT GR, et al. STILBAZIUM IODIDE IN THE MASS TREATMENT OF MICE INFECTED WITH SYPHACIA OBVELATA. J Parasitol. 1963 Dec;49:1019-20. [Content Brief]
[4]. SWARTZWELDER JC, et al. STILBAZIUM IODIDE (MONOPAR). AN EFFECTIVE, SINGLE DOSE ANTHELMINTHIC FOR TREATMENT OF ENTEROBIUS VERMICULARIS INFECTION. Clin Pediatr (Phila). 1963 Dec;2:701-2. [Content Brief]
[5]. JEFFERY GM, et al. EFFECT OF STILBAZIUM IODIDE ON ENTEROBIUS VERMICULARIS AND OTHER INTESTINAL HELMINTHS. J Parasitol. 1963 Aug;49:639-41. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Stilbazium iodide Related Classifications
HY-184082 Related Classifications
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