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Cat. No.: HY-183053

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UCP1173

UCP1173, propargyl-linked antifolate, is an antibacterial agent. UCP1173 inhibits DHFR enzymes, with IC₅₀ values of 0.014 μM for DfrB, 0.19 μM for DfrG, 0.27 μM for DfrA, and 0.091 μM for DfrK. UCP1173 inhibits growth of Staphylococcus aureus clinical isolates carrying dfrA, dfrG, or dfrK resistance genes. UCP1173 can be used for the research of bacterial infections.

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CAS No.: 1922152-09-7
Formule: C₂₄H₂₄N₄O₃
Masse moléculaire:416.48

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Please store the product under the recommended conditions in the Certificate of Analysis.

UCP1173 Chemical Structure

CAS No.: 1922152-09-7

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Antibody-Drug Conjugates

One-stop solution for XDC (ADC/PDC/RDC/ApDC/FDC/ISAC/VDC/SMDC)

Activité biologique
- Description
- Cellular Effect
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
Bioz

Activité biologique

Description

Cellular Effect

Cell Line	Type	Value	Description	References
MCF-10A	IC₅₀	100 μM Compound: 11S	Cytotoxicity against human MCF10A cells after 4 hrs by alamar blue assay Cytotoxicity against human MCF10A cells after 4 hrs by alamar blue assay	[PMID: 27437079]

In Vitro

UCP1173 potently inhibits the growth of Trimethoprim (HY-B0510)-resistant MRSA/MSSA isolates carrying dfrG, dfrA, or dfrK, with MIC values ranging from 1.25 to 5 μg/mL for resistant strains, and shows high activity against wild-type ATCC 43300 S. aureus with an MIC of 0.0098 μg/mL^[1].
UCP1173 potently inhibits wild-type and TMP-resistant S. aureus DHFR enzymes, with IC₅₀ values of 0.014 μM for DfrB, 0.19 μM for DfrG, 0.27 μM for DfrA, and 0.091 μM for DfrK^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1922152-09-7
Masse moléculaire 416.48
Formule C₂₄H₂₄N₄O₃
SMILES

[C@H](C#CC=1C(CC)=NC(N)=NC1N)(C)C=2C=C(C=C(OC)C2)C3=CC=C(C(O)=O)C=C3
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Reeve SM, et al. MRSA Isolates from United States Hospitals Carry dfrG and dfrK Resistance Genes and Succumb to Propargyl-Linked Antifolates. Cell Chem Biol. 2016;23(12):1458-1467. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

100 mg

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